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Functional System and Areal Organization of a Highly Sampled Individual Human Brain
The brain organization of a single individual repeatedly measured over more than a year is characterized and a reproducible and internally valid subject-specific areal-level parcellation that corresponds with subject- specific task activations is reported. Expand
Deconvolving BOLD activation in event-related designs for multivoxel pattern classification analyses
The present work compares 8 different models for estimating trial-by-trial activation patterns for a range of rapid event-related designs varying by interstimulus interval and signal-to-noise ratio and finds that the most effective approach obtains each trial's estimate through a general linear model including a regressor for that trial as well as another regression for all other trials. Expand
Greater Neural Pattern Similarity Across Repetitions Is Associated with Better Memory
This result addresses a longstanding debate in the study of memory by showing that successful episodic memory encoding occurs when the same neural representations are more precisely reactivated across study episodes, rather than when patterns of activation are more variable across time. Expand
Striatal Dopamine D2/D3 Receptor Availability Is Reduced in Methamphetamine Dependence and Is Linked to Impulsivity
The findings suggest that low striatal D2/D3 receptor availability may mediate impulsive temperament and thereby influence addiction. Expand
Learning-related representational changes reveal dissociable integration and separation signatures in the hippocampus and prefrontal cortex
High-resolution functional magnetic resonance imaging in humans is used to examine how representations of memory elements change to either differentiate or generalize across related events and highlights how memory elements are represented to simultaneously promote generalization across memories and protect from interference. Expand
Engagement of large-scale networks is related to individual differences in inhibitory control
Results clearly show a relationship between individual differences in stopping ability in specific activated networks, including regions known to be critical for the behavior, and highlight the usefulness of using dimensionality reduction to increase the power to detect brain/behavior correlations in individual differences research. Expand
Long-term neural and physiological phenotyping of a single human
The MyConnectome project demonstrates dynamic changes in brain connectivity over the timescales of days to months, and relations between brain connectivity, gene expression and metabolites. Expand
Altered Functional Connectivity in Frontal Lobe Circuits Is Associated with Variation in the Autism Risk Gene CNTNAP2
Using functional neuroimaging, a relationship between frontal lobar connectivity and common genetic variants in CNTNAP2 is demonstrated, providing a mechanistic link between specific genetic risk for neurodevelopmental disorders and empirical data implicating dysfunction of long-range connections within the frontal lobe in autism. Expand
A phenome-wide examination of neural and cognitive function
This data descriptor outlines a shared neuroimaging dataset from the UCLA Consortium for Neuropsychiatric Phenomics, which focused on understanding the dimensional structure of memory and cognitiveExpand