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Developmental changes in hemodynamics of uterine artery, utero- and umbilicoplacental, and vitelline circulations in mouse throughout gestation.
In human pregnancy, abnormal placental hemodynamics likely contribute to the etiology of early-onset preeclampsia and fetal intrauterine growth restriction. The mouse is increasingly being deployed… Expand
Myometrial Apoptosis: Activation of the Caspase Cascade in the Pregnant Rat Myometrium at Midgestation1
Abstract In the present study, we determined the contribution of myometrial hyperplasia, hypertrophy, and apoptosis to uterine growth during pregnancy. The changes in two endogenous markers of cell… Expand
Endothelial Nitric Oxide Synthase Deficiency Reduces Uterine Blood Flow, Spiral Artery Elongation, and Placental Oxygenation in Pregnant Mice
- S. Kulandavelu, K. Whiteley, Dawei Qu, J. Mu, S. Bainbridge, S. Adamson
- 1 July 2012
Preeclampsia is associated with impaired uteroplacental adaptations during pregnancy and abnormalities in the endothelial NO synthase (eNOS)-NO pathway, but whether eNOS deficiency plays a causal… Expand
Embryonic and neonatal phenotyping of genetically engineered mice.
Considerable progress has been made in adapting existing and developing new technologies to enable increasingly detailed phenotypic information to be obtained in embryonic and newborn mice.… Expand
Effects of neonatal hypoxic–ischemic brain injury on skilled motor tasks and brainstem function in adult rats
In an attempt to establish more sensitive long-term neurofunctional measurements for neonatal hypoxic-ischemic brain injury, we examined skilled motor task and brainstem functions in adult rats after… Expand
Ultrasonic detection and developmental changes in calcification of the placenta during normal pregnancy in mice.
High resolution ultrasound imaging of the mouse placenta during development revealed highly echogenic foci localized near the materno-placental interface in early gestation and, near term, in the… Expand
Antenatal prediction of pulmonary hypoplasia by acceleration time/ejection time ratio of fetal pulmonary arteries by Doppler blood flow velocimetry.
OBJECTIVE The purpose of this study was to develop a new method for the antenatal prediction of pulmonary hypoplasia by Doppler blood flow velocimetry. STUDY DESIGN One hundred seventy-seven… Expand
In vivo quantification of embryonic and placental growth during gestation in mice using micro-ultrasound
- J. Mu, J. C. Slevin, Dawei Qu, Sarah McCormick, S. Adamson
- Biology, Medicine
- Reproductive biology and endocrinology : RB&E
- 12 August 2008
BackgroundNon-invasive micro-ultrasound was evaluated as a method to quantify intrauterine growth phenotypes in mice. Improved methods are required to accelerate research using genetically-altered… Expand
Long-Term Neuroprotective Effects of Hypothermia on Neonatal Hypoxic-Ischemic Brain Injury in Rats, Assessed by Auditory Brainstem Response
A method to assess long-term neurofunctional outcome of hypothermia on immature brains has not yet been clearly established. To investigate the effects of hypothermia on long-term neurofunctional… Expand
Effects of hyperthermia on hypoxic-ischemic brain damage in the immature rat: its influence on caspase-3-like protease.
- T. Tomimatsu, H. Fukuda, Takeshi Kanagawa, J. Mu, T. Kanzaki, Y. Murata
- Biology, Medicine
- American journal of obstetrics and gynecology
- 1 March 2003
OBJECTIVE Recent clinical studies suggested that intrapartum maternal fever is a strong independent risk factor for neonatal encephalopathy. With use of a well-studied rat model of neonatal… Expand