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Type VI secretion is a major virulence determinant in Burkholderia mallei
It is shown with expression profiling that overexpression of virAG resulted in transcriptional activation of ∼60 genes, including some involved in capsule production, actin‐based intracellular motility, and type VI secretion (T6S) in hamsters, and BMAA0742 was secreted by the T6S system when virAG was overexpressed. Expand
Compositional biases of bacterial genomes and evolutionary implications
Compared and contrast genome-wide compositional biases and distributions of short oligonucleotides across 15 diverse prokaryotes, finding that the dinucleotide CpG=CG is underrepresented in many thermophiles but overrepresented in halobacteria, and possible mechanisms underlying the genome signature, the form and level of genome compositional flux. Expand
Comparative DNA analysis across diverse genomes.
We review concepts and methods for comparative analysis of complete genomes including assessments of genomic compositional contrasts based on dinucleotide and tetranucleotide relative abundanceExpand
Predicted Highly Expressed Genes of Diverse Prokaryotic Genomes
The three protein families-ribosomal proteins, protein synthesis factors, and chaperone complexes-are needed at many stages of the life cycle, and apparently bacteria have evolved codon usage to maintain appropriate growth, stability, and plasticity. Expand
Amino acid runs in eukaryotic proteomes and disease associations
It is found that human proteins with multiple long runs are often associated with diseases; these include long glutamine runs that induce neurological disorders, various cancers, categories of leukemias (mostly involving chromosomal translocations), and an abundance of Ca2 + and K+ channel proteins. Expand
Strand compositional asymmetry in bacterial and large viral genomes.
  • J. Mrázek, S. Karlin
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 31 March 1998
Several bacterial genomes exhibit preference for G over C on the DNA leading strand extending from the origin of replication to the ter-region in the genomes of Escherichia coli, MycoplasmaExpand
Compositional differences within and between eukaryotic genomes.
  • S. Karlin, J. Mrázek
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 16 September 1997
The genome signature differences have implications for contrasts between rodents and other mammals, and between monocot and dicot plants, as well as providing evidence for similarities among fungi and the diversity of protists. Expand
Genome signature comparisons among prokaryote, plasmid, and mitochondrial DNA.
Genome signature comparisons show that plasmids, both specialized and broad-range, and their hosts have substantially compatible (similar) genome signatures, and the archaea are not a coherent clade. Expand
Characterizations of Highly Expressed Genes of Four Fast-Growing Bacteria
ABSTRACT Predicted highly expressed (PHX) genes are characterized for the completely sequenced genomes of the four fast-growing bacteriaEscherichia coli,Haemophilus influenzae, Vibrio cholerae, andExpand
Epstein-Barr Virus-Encoded Latent Membrane Protein 1 (LMP1) Induces the Expression of the Cellular MicroRNA miR-146a
It is shown that the EBV-encoded latent membrane protein 1 (LMP1) induces the expression of miR-146a via NF-κB, which is involved in sequence-specific cleavage, translational repression or deadenylation of specific target mRNAs resulting in post-transcriptional gene silencing. Expand