• Publications
  • Influence
Percutaneous absorption of N,N-dimethylformamide in humans
TLDR
Skin penetration fo N,N-dimethylformamide (DMF) liquid or vapour was studied in volunteers and the contention that AMCC should be used instead of “MF” as the most suitable biomarker of DMF in cases where percutaneous intake can occur is supported. Expand
New selective inhibitors of cytochromes P450 2B and their application to antimutagenesis of tamoxifen.
TLDR
2-PMADA and 3-PMDIA are very potent for inhibition of formation of these DNA adducts and warrant consideration as candidates for preventing endometrial cancer development by tamoxifen in humans treated with this anticancer drug. Expand
Investigation of the mechanistic basis of N,N-dimethylformamide toxicity. Metabolism of N,N-dimethylformamide and its deuterated isotopomers by cytochrome P450 2E1.
Dimethylformamide (DMF) is an industrial solvent with hepatotoxic properties. The toxicity of DMF has been associated with its metabolism to S-(N-methylcarbamoyl)glutathione (SMG). The major urinaryExpand
Metabolism of benzene in human liver microsomes: individual variations in relation to CYP2E1 expression
Abstract In human liver microsomes the oxidations of benzene, chlorzoxazone, aniline, dimethylformamide, and 4-nitrophenol were significantly correlated with each other and with the level ofExpand
Absorption, metabolism and elimination of N,N-dimethylformamide in humans
TLDR
In contrast to slow elimination of AMCC after exposure toDMF, AMCC was eliminated rapidly after AMCC intake, which could be explained by rate-limiting reversible protein binding of a reactive metabolic intermediate of DMF, possibly methylisocyanate. Expand
Differences between rodents and humans in the metabolic toxification of N,N-dimethylformamide.
TLDR
There is a quantitative difference between the metabolic pathway ofDMF to AMCC in humans and rodents and it is argued that the hepatotoxic potential of DMF may be linked to the extent of its metabolic conversion to AM CC. Expand
Improved gas chromatographic-mass spectrometric determination of the N-methylcarbamoyl adduct at the N-terminal valine of globin, a metabolic product of the solvent N,N-dimethylformamide.
TLDR
Toxicokinetic studies in volunteers laid the grounds for setting the reference value for biological monitoring of occupational exposure to DMF, and has been used to determine the background levels of MVH in unexposed subjects. Expand
Severe pulmonary toxoplasmosis after allo-SCT in two patients: from Toxoplasma genotyping to clinical management
Severe pulmonary toxoplasmosis after allo-SCT in two patients: from Toxoplasma genotyping to clinical management
Biological monitoring of N,N-dimethylformamide. Reference value for N-methylcarbamoyl adduct at the N-terminal valine of globin as a biomarker of chronic occupational exposure
TLDR
The value of 135 nmol MVH/g globin is recommended to be used as a new reference value for biomonitoring of integrated exposure to DMF over a long period. Expand
1,2- and 1,4-Cyclohexanediol: major urinary metabolites and biomarkers of exposure to cyclohexane, cyclohexanone, and cyclohexanol in humans
TLDR
Determination of CH-diols in end-of-shift urine samples is recommended as a useful new method of biomonitoring of CH, CH-ol, and CH-one at the workplace, however, due to accumulation of H2O in the body during repeated exposure, quantitative relationships between the exposure and the level of CHs have to be adjusted according to the day of sampling during the working week. Expand
...
1
2
3
4
5
...