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Detecting immigration by using multilocus genotypes.
TLDR
The test has power to detect immigrant ancestors, for these data, up to two generations in the past even though the overall differentiation of allele frequencies among populations is low. Expand
Diet and the evolution of human amylase gene copy number variation
TLDR
It is found that copy number of the salivary amylase gene (AMY1) is correlated positively with salivaries protein level and that individuals from populations with high-starch diets have, on average, more AMY1 copies than those with traditionally low-st starch diets. Expand
Ancient human genomes suggest three ancestral populations for present-day Europeans
TLDR
It is shown that the great majority of present-day Europeans derive from at least three highly differentiated populations: West European Hunter-Gatherers (WHG), who contributed ancestry to all Europeans but not to Near Easterners; Ancient North Eurasians (ANE); and Early European Farmers (EEF), who were mainly of Near Eastern origin but also harbored WHG-related ancestry. Expand
The Genetic Ancestry of African Americans, Latinos, and European Americans across the United States
TLDR
It is shown that regional ancestry differences reflect historical events, such as early Spanish colonization, waves of immigration from many regions of Europe, and forced relocation of Native Americans within the US, which informs the understanding of the relationship between racial and ethnic identities and genetic ancestry. Expand
History of click-speaking populations of Africa inferred from mtDNA and Y chromosome genetic variation.
TLDR
New genetic data show that the Sandawe and southern African click speakers share rare mtDNA and Y chromosome haplogroups; however, common ancestry of the 2 populations dates back >35,000 years, which suggests that at the time of the spread of agriculture and pastoralism, the click-speaking populations were already isolated from one another. Expand
The importance of race and ethnic background in biomedical research and clinical practice.
TLDR
With the completion of a rough draft of the human genome, some have suggested that racial classification may not be useful for biomedical studies, since it reflects “a fairly small number of genes that describe appearance” and “there is no basis in the genetic code for race. Expand
Drift, admixture, and selection in human evolution: a study with DNA polymorphisms.
TLDR
A reconstruction of human differentiation based on 100 DNA polymorphisms tested in five populations from four continents shows that Europeans do not fit a simple model of independently evolving populations with equal evolutionary rates, and evolutionary models involving early admixture are compatible with the data. Expand
Web-Based Genome-Wide Association Study Identifies Two Novel Loci and a Substantial Genetic Component for Parkinson's Disease
TLDR
A substantial, but by no means total, contribution of genetics underlying susceptibility to both early-onset and late-ONSet PD is indicated, suggesting that, despite the novel associations discovered here and elsewhere, the majority of the genetic component for Parkinson's disease remains to be discovered. Expand
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
TLDR
Evidence is reported for the involvement of many systems in tobacco and alcohol use, including genes involved in nicotinic, dopaminergic, and glutamatergic neurotransmission, which provide a solid starting point to evaluate the effects of these loci in model organisms and more precise substance use measures. Expand
Genome-Wide Analysis Points to Roles for Extracellular Matrix Remodeling, the Visual Cycle, and Neuronal Development in Myopia
TLDR
The largest ever genome-wide association study on myopia in Europeans performs a survival analysis on age of myopia onset and identifies 22 significant associations, two of which are replications of earlier associations with refractive error. Expand
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