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Review on some antioxidant plants growing in Arab world
Abstract Cellular damage or oxidative injury arising from free radicals or reactive oxygen species (ROS) now appears the fundamental mechanism underlying a number of human neurodegenerative
The growing applications of click chemistry.
This tutorial review examines the copper(I)-catalysed 1,2,3-triazole forming reaction between azides and terminal alkynes, which has become the gold standard of click chemistry due to its reliability, specificity and biocompatibility.
Stabilization of G-quadruplex DNA by highly selective ligands via click chemistry.
A series of G-quadruplex stabilizing compounds prepared via click chemistry employing the Cu(I)-catalyzed Huisgen reaction were shown to bind tightly to G- quadruplex DNA even in the presence of competing high concentrations of duplex DNA.
Selectivity of small molecule ligands for parallel and anti-parallel DNA G-quadruplex structures.
It is demonstrated that two different small molecule architectures result in significant differences in selectivity for parallel and anti-parallel quadruplex structures that may guide quadruplex targeted drug-design.
Carbene footprinting accurately maps binding sites in protein–ligand and protein–protein interactions
The much improved properties of this probe make carbene footprinting a viable method for rapid and accurate identification of protein binding sites utilizing benign, near-UV photoactivation.
The total synthesis of spectinabilin and its biomimetic conversion to SNF4435C and SNF4435D.
A short synthesis of (+/-)-spectinabilin via a trans-selective Suzuki coupling and subsequent Negishi-type methylation, and its biomimetic conversion to (-/-)-SNF4435C and (+/--SNF 4435D is described.
G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo.
In vivo tumour xenograft studies with the A549 lung cancer model and the trisubstituted acridine compound AS1410 showed only a modest anti-tumour effect when administered alone, but produced rapid and highly significant decreases in tumour volume when administered in combination with cis-platin.
Structural characterization of the apo form and NADH binary complex of human lactate dehydrogenase
A crystal structure of the human lactate dehydrogenase A apo form suitable for ligand soaking and a NADH binary-complex structure are presented.