J. Moseley

Publications68
h-index28
Citations3,767
Highly Influential Citations338
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An actin nucleation mechanism mediated by Bni1 and Profilin
Formins are required for cell polarization and cytokinesis, but do not have a defined biochemical activity. In Saccharomyces cerevisiae, formins and the actin-monomer-binding protein profilin are… Expand
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A spatial gradient coordinates cell size and mitotic entry in fission yeast
Many eukaryotic cell types undergo size-dependent cell cycle transitions controlled by the ubiquitous cyclin-dependent kinase Cdk1 (refs 1–4). The proteins that control Cdk1 activity are well… Expand
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The Yeast Actin Cytoskeleton: from Cellular Function to Biochemical Mechanism
  • J. Moseley, B. Goode
  • Biology, Medicine
  • Microbiology and Molecular Biology Reviews
  • 1 September 2006
SUMMARY All cells undergo rapid remodeling of their actin networks to regulate such critical processes as endocytosis, cytokinesis, cell polarity, and cell morphogenesis. These events are driven by… Expand
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Crystal Structures of a Formin Homology-2 Domain Reveal a Tethered Dimer Architecture
Formin proteins participate in a wide range of cytoskeletal processes in all eukaryotes. The defining feature of formins is a highly conserved approximately 400 residue region, the Formin Homology-2… Expand
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The formin mDia2 stabilizes microtubules independently of its actin nucleation activity
A critical microtubule (MT) polarization event in cell migration is the Rho/mDia-dependent stabilization of a subset of MTs oriented toward the direction of migration. Although mDia nucleates actin… Expand
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A conserved mechanism for Bni1- and mDia1-induced actin assembly and dual regulation of Bni1 by Bud6 and profilin.
Formins have conserved roles in cell polarity and cytokinesis and directly nucleate actin filament assembly through their FH2 domain. Here, we define the active region of the yeast formin Bni1 FH2… Expand
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A high-affinity interaction with ADP-actin monomers underlies the mechanism and in vivo function of Srv2/cyclase-associated protein.
Cyclase-associated protein (CAP), also called Srv2 in Saccharomyces cerevisiae, is a conserved actin monomer-binding protein that promotes cofilin-dependent actin turnover in vitro and in vivo.… Expand
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Adenomatous polyposis coli protein nucleates actin assembly and synergizes with the formin mDia1
The microtubule regulator APC is now shown to also regulate actin filament dynamics through its C-terminal “Basic” domain.
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Differential Activities and Regulation of Saccharomyces cerevisiae Formin Proteins Bni1 and Bnr1 by Bud6*
Formins are conserved proteins that nucleate actin assembly and tightly associate with the fast growing barbed ends of actin filaments to allow insertional growth. Most organisms express multiple… Expand
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The filament-forming protein Pil1 assembles linear eisosomes in fission yeast
Eisosomes generate spatial domains in the plasma membrane of yeast cells. The core eisosome protein Pil1 is shown to form filaments in vitro and in cells. Pil1 filaments are stable at the cell… Expand
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