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EffiCiency and Safety of an eLectronic cigAreTte (ECLAT) as Tobacco Cigarettes Substitute: A Prospective 12-Month Randomized Control Design Study
TLDR
In smokers not intending to quit, the use of e-cigarettes, with or without nicotine, decreased cigarette consumption and elicited enduring tobacco abstinence without causing significant side effects.
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Effect of an electronic nicotine delivery device (e-Cigarette) on smoking reduction and cessation: a prospective 6-month pilot study
TLDR
The use of e-Cigarette substantially decreased cigarette consumption without causing significant side effects in smokers not intending to quit, and perception and acceptance of the product was good.
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Chemokine Receptor 4 Plays a Key Role in T Cell Recruitment into the Airways of Asthmatic Patients
TLDR
Evidence is provided that CCR4 might play a role in allergen-driven Th2 cell accumulation in asthmatic airways and Targeting this chemokine receptor in patients with asthma might reduce Th 2 cell-driven airway inflammation; therefore, C CR4 antagonists could be an effective new therapy for asthma.
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Effect of acute exacerbations on circulating endothelial, clotting and fibrinolytic markers in COPD patients
TLDR
The pro-thrombotic nature of COPD exacerbations sustained by enhanced clotting activation appears to be mitigated by excessive fibrinolysis, and elevation of IL-6, vWF, D-D and F1+2 levels implies a strict association between acute inflammation, endothelial activation and clotting initiation.
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Effectiveness and tolerability of electronic cigarette in real-life: a 24-month prospective observational study
TLDR
Long-term e-Cigarette use can substantially decrease cigarette consumption in smokers not willing to quit and is well tolerated.
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Effect of Smoking Abstinence and Reduction in Asthmatic Smokers Switching to Electronic Cigarettes: Evidence for Harm Reversal
TLDR
It is indicated that regular use of e-cigs to substitute smoking is associated with objective and subjective improvements in asthma outcomes, and shows that e-Cigs can be a valid option for asthmatic patients who cannot quit smoking by other methods.
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Anti-IgE – emerging opportunities for Omalizumab
TLDR
This review aims to look at the various randomised and non-randomised clinical trials, case series and case reports for the role of Omalizumab in conditions other than asthma.
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Inhaled corticosteroids in chronic obstructive pulmonary disease: a pro–con perspective
TLDR
Clinicians need to be aware of the heterogeneity as well as having an understanding of how ICS may be used in the context of the specific subgroups of patients with COPD, according to the currently available evidence.
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Umeclidinium in chronic obstructive pulmonary disease: latest evidence and place in therapy
TLDR
Both Umec alone and in combination with Vil delivered through a multi-dose dry powder Elliptaâ„¢ device have shown improvement in lung function, health-related quality of life and exacerbation frequency in patients with COPD.
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Evidence for harm reduction in COPD smokers who switch to electronic cigarettes
TLDR
It is suggested that ECs use may aid smokers with COPD reduce their cigarette consumption or remain abstinent, which results in marked improvements in annual exacerbation rate as well as subjective and objective COPD outcomes.
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