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NF-kappaB in renal inflammation.
The NF-kappaB family of transcription factors regulates the induction and resolution of inflammation. Two main pathways, classical and alternative, control the nuclear translocation of NF-kappaB.Expand
The inflammatory cytokines TWEAK and TNFα reduce renal klotho expression through NFκB.
Proinflammatory cytokines contribute to renal injury, but the downstream effectors within kidney cells are not well understood. One candidate effector is Klotho, a protein expressed by renal cellsExpand
Comparative study of propofol versus midazolam in the sedation of critically ill patients: results of a prospective, randomized, multicenter trial.
OBJECTIVES To compare the effectiveness, characteristics, duration of action, hemodynamic and biochemical effects, and side effects of propofol and midazolam used for continuous intravenous sedationExpand
Molecular Mechanisms and Novel Therapeutic Approaches to Rhabdomyolysis-Induced Acute Kidney Injury
Rhabdomyolysis is a syndrome caused by injury to skeletal muscle that usually leads to acute kidney injury (AKI). Rhabdomyolysis has been linked to different conditions, including severe trauma andExpand
Phenolic content of virgin olive oil improves ischemic reactive hyperemia in hypercholesterolemic patients.
OBJECTIVES The goal of this study was to evaluate the effects of the phenolic content of virgin olive oil on endothelial reactivity. BACKGROUND Endothelial-dependent vasodilatation is impairedExpand
The CD163-expressing macrophages recognize and internalize TWEAK: potential consequences in atherosclerosis.
BACKGROUND CD163 is a new potential scavenger receptor of Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) which elicits diverse biologic actions involved in atherosclerosis. We haveExpand
HDL antielastase activity prevents smooth muscle cell anoikis, a potential new antiatherogenic property
Various studies using proteomic approaches have shown that HDL can carry many proteins other than its constitutive apolipoprotein A‐I (apoA‐I). Using mass spectrometry and Western blotting, we showedExpand
Basal plasma concentrations of plant sterols can predict LDL-C response to sitosterol in patients with familial hypercholesterolemia
Background:Familial hypercholesterolemia (FH) is associated with a high risk of coronary heart disease. Pharmacological treatment and diet are both essential for the management of FH. Foods rich inExpand
Erythrocytes, leukocytes and platelets as a source of oxidative stress in chronic vascular diseases: detoxifying mechanisms and potential therapeutic options.
Oxidative stress is involved in the chronic pathological vascular remodelling of both abdominal aortic aneurysm and occlusive atherosclerosis. Red blood cells (RBCs), leukocytes and platelets presentExpand
Soluble TWEAK is associated with atherosclerotic burden in patients with chronic kidney disease.
BACKGROUND Chronic kidney disease (CKD) is characterized by a high mortality rate, primarily due to cardiovascular disease. Reduced soluble TNF-like weak inducer of apoptosis (sTWEAK) levels haveExpand