• Publications
  • Influence
On the formulation of pH-sensitive liposomes with long circulation times.
Strategies used to enhance liposome-mediated drug delivery in vivo include the enhancement of stability and circulation time in the bloodstream, targeting to specific tissues or cells, andExpand
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Lipid-based nanoparticles for siRNA delivery in cancer therapy: paradigms and challenges.
RNA interference (RNAi) is a specific gene-silencing mechanism that can be mediated by the delivery of chemical synthesized small-interfering RNA (siRNA). RNAi might constitute a novel therapeuticExpand
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Use of the Post-Insertion Technique to Insert Peptide Ligands into Pre-Formed Stealth Liposomes with Retention of Binding Activity and Cytotoxicity
AbstractPurpose: Simple methods for the large-scale manufacture of ligand-targeted liposomes will be needed if clinical trials are to proceed. We tested a recently developed technology for insertingExpand
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Combination Chemotherapy in Cancer: Principles, Evaluation and Drug Delivery Strategies
Cancer is a major public health problem since it is the second leading cause of illness-related death, only exceeded by heart disease (American Cancer Society [ACS], (2010)). Cancer results fromExpand
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Bridging cancer biology and the patients' needs with nanotechnology-based approaches.
Cancer remains as stressful condition and a leading cause of death in the western world. Actual cornerstone treatments of cancer disease rest as an elusive alternative, offering limited efficacy withExpand
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Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis
Epileptic seizures and anxiety crisis are severe conditions that require fast and effective treatment, targeting the brain. Current emergency antiepiletics and anxiolytics have limited brainExpand
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Challenging the future of siRNA therapeutics against cancer: the crucial role of nanotechnology
The identification of numerous deregulated signaling pathways on cancer cells and supportive stromal cells has revealed several molecular targets whose downregulation can elicit significant benefitsExpand
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Tumor-targeted Chlorotoxin-coupled Nanoparticles for Nucleic Acid Delivery to Glioblastoma Cells: A Promising System for Glioblastoma Treatment
The present work aimed at the development and application of a lipid-based nanocarrier for targeted delivery of nucleic acids to glioblastoma (GBM). For this purpose, chlorotoxin (CTX), a peptideExpand
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Bcl-2-targeted antisense therapy (Oblimersen sodium): towards clinical reality.
The identification of activated oncogenes, such as the bcl-2, in several types of cancer has made it possible to consider such genes as targets for antitumor therapy. Bcl-2 is an anti-apoptoticExpand
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Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype.
Others and we showed that RNA interference holds great promise for the treatment of dominantly inherited neurodegenerative disorders such as Machado-Joseph disease (MJD), for which there is noExpand
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