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Radical reduction in the rate of extensive corrective surgery for clubfoot using the Ponseti method.
OBJECTIVES The purpose of this study was to evaluate the efficacy of the Ponseti method in reducing extensive corrective surgery rates for congenital idiopathic clubfoot. METHODS Consecutive caseExpand
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Early attempts at hip arthroplasty--1700s to 1950s.
Over the last three centuries, treatment of hip arthritides has evolved from rudimentary surgery to modern total hip arthroplasty (THA), which is considered one of the most successful surgicalExpand
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Two novel point mutations in the long‐range SHH enhancer in three families with triphalangeal thumb and preaxial polydactyly
Spatio‐temporal expression of sonic hedgehog (SHH) is driven by a regulatory element (ZRS) that lies 1 Mb upstream from SHH. Point mutations within the highly conserved ZRS have been described in theExpand
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CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis.
Idiopathic scoliosis (IS) is the most common spinal deformity in children, and its etiology is unknown. To refine the search for genes underlying IS susceptibility, we ascertained a new cohort of 52Expand
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Results of an Accelerated Ponseti Protocol for Clubfoot
The Ponseti method has demonstrated excellent results when performed at weekly intervals, but it is not known whether correction can be accomplished in a shorter amount of time. This study evaluatedExpand
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Treatment of the Complex Idiopathic Clubfoot
Treatment with the Ponseti method corrects congenital idiopathic clubfeet in the majority of patients. However, some feet do not respond to the standard treatment protocol. We describe theExpand
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Biofilm dispersal of community‐associated methicillin‐resistant Staphylococcus aureus on orthopedic implant material
Orthopedic implant‐related bacterial infections are associated with high morbidity that may lead to limb amputation and exert significant financial burden on the healthcare system. StaphylococcusExpand
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A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes
We report a mouse model of multiple osteochondromas (MO), an autosomal dominant disease in humans, also known as multiple hereditary exostoses (MHE or HME) and characterized by the formation ofExpand
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Correction of neglected idiopathic club foot by the Ponseti method.
The Ponseti method of treating club foot has been shown to be effective in children up to two years of age. However, it is not known whether it is successful in older children. We retrospectivelyExpand
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Adolescent idiopathic scoliosis
Adolescent idiopathic scoliosis (AIS) affects 1-3% of children in the at-risk population of those aged 10-16 years. The aetiopathogensis of this disorder remains unknown, with misinformation aboutExpand
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