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Photochemotherapy using pyridopsoralens.
TLDR
In diploid eukaryotic yeast they are more effective than 8-MOP for the induction of lethal effects and mitochondrial damage, and in mammalian cells the following ranges of effectiveness are found: inhibition of DNA synthesis in human fibroblasts; mutagenic activity in V79 Chinese hamster cells; cell transforming ability in C3H embryonic mouse cells. Expand
FA-70, a novel selective and irreversible monoamine oxidase-A inhibitor: effect on monoamine metabolism in mouse cerebral cortex.
TLDR
The ex vivo effect of FA70 on dopamine content was correlated with the activation effect on tyrosine hydroxylase activity, the enzyme responsible for the regulation of the limiting step in catecholamine synthesis. Expand
SPECTROSCOPIC PROPERTIES AND PHOTOREACTIVITY WITH DNA OF NEW MONOFUNCTIONAL PYRIDOPSORALENS
TLDR
New psoralen derivatives have been synthesized in order to enhance their affinity towards DNA, and the monofunctional character has also been established for psoralens having a fused pyridine ring in the 4′, 5′ site. Expand
Molecular determinants of MAO selectivity in a series of indolylmethylamine derivatives: biological activities, 3D-QSAR/CoMFA analysis, and computational simulation of ligand recognition.
TLDR
Comparing the steric and electrostatic properties at the 5 position of the indole ring are determinant for MAO selectivity and Computational simulations of the complex between this part of the ligand and Phe-208 or Ile-199 of MAO-B allowed us to further characterize the nature of these enzyme-inhibitor interactions. Expand
Synthesis of 5H-furo[3′,2′ : 6,7][1]benzopyrano[3,4-c]pyridin-5-ones and 8H-pyrano[3′,2′ : 5,6]benzofuro[3,2-c]pyridin-8-ones (pyridopsoralens)
5H-Furo[3′,2′ : 6,7][1]benzopyrano[3,4-c]pyridin-5-ones (pyrido[3,4-c]psoralens)(3) have been obtained by the von Pechmann reaction starting from 6-hydroxy-2,3-dihydrobenzofuran acetates plusExpand
Frameshift mutagenicity in Salmonella typhimurium of furocoumarins in the dark.
TLDR
The dark mutagenicity of 4,5',8-trimethylpsoralen (4,5,8-TMP, 8-MOP and the two pyridopsoralens were found to be weak frameshift mutagens in strain TA1537 whereas 5-Mop and 3-CPs did not demonstrate any significant mutagenic activity, supporting the notion that the genetic risks of these psoralens in the dark may be considered to be negligible. Expand
Evidence of a coupled mechanism between monoamine oxidase and peroxidase in the metabolism of tyramine by rat intestinal mitochondria.
TLDR
The results indicate that the peroxidase-dependent metabolism of tyramine in the gut may be driven by H2O2 produced by MAO activities and that MAO-A is mainly responsible for this process, as well as for the oxidative deamination of tyramsine. Expand
EFFECT OF MOLECULAR STRUCTURE ON THE PHOTOPHYSICAL PROPERTIES, THE PHOTOREACTIVITY WITH DNA AND THE PHOTOBIOLOGICAL ACTIVITY OF MONOFUNCTIONAL PYRIDOPSORALENS
TLDR
2N‐MePyPs has only a weak antiproliferative potential and, per unit dose, a lower capacity than MePyPs for the induction of nuclear genotoxic effects, and resembles the monofunctional furocoumarin 3‐CPs. Expand
Biosynthesis of porphyrins and related macrocycles. Part II. Synthesis of δ-amino[5-13C]laevulinic acid and [11-13C] porphobilinogen: incorporation of the latter into protoporphyrin-IX
A short synthesis of δ-aminolaevulinic acid is described in which C-5 and the nitrogen atom are introduced as cyanide ion. The sequence is especially well suited to the preparation of materialExpand
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