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CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions.
Rats and mice exhibit a spontaneous attraction for lipids. Such a behavior raises the possibility that an orosensory system is responsible for the detection of dietary lipids. The fatty acidExpand
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A family of candidate taste receptors in human and mouse
The gustatory system of mammals can sense four basic taste qualities, bitter, sweet, salty and sour, as well as umami, the taste of glutamate. Previous studies suggested that the detection of bitterExpand
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A candidate taste receptor gene near a sweet taste locus
The mechanisms underlying sweet taste in mammals have been elusive. Although numerous studies have implicated G proteins in sweet taste detection, the expected G protein-coupled receptors have notExpand
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The gustatory pathway is involved in CD36‐mediated orosensory perception of long‐chain fatty acids in the mouse
The sense of taste informs the body about the quality of ingested foods. Tastant‐mediated signals are generated by a rise in free intracellular calcium levels ([Ca2+]i) in the taste bud cells andExpand
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Endothelin receptors and pain.
UNLABELLED The endogenous endothelin (ET) peptides participate in a remarkable variety of pain-relatedprocesses. Pain that is elevated by inflammation, by skin incision, by cancer, during a SickleExpand
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Nonsynonymous single nucleotide polymorphisms in human tas1r1, tas1r3, and mGluR1 and individual taste sensitivity to glutamate.
Several studies indicate an essential role of the heterodimer Tas1R1-Tas1R3 for monosodium l-glutamate (MSG) detection, although others suggest alternative receptors. Human subjects show differentExpand
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Genetic tracing reveals a stereotyped sensory map in the olfactory cortex
The olfactory system translates myriad chemical structures into diverse odour perceptions. To gain insight into how this is accomplished, we prepared mice that coexpressed a transneuronal tracer withExpand
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Receptors for bitter and sweet taste
The identification of two families of receptors, T1Rs and T2Rs, for sweet and bitter taste stimuli has opened the door to understanding some of the basic mechanisms underlying taste transduction inExpand
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Fat Detection: Taste, Texture, and Post Ingestive Effects
IMPORTANCE OF DIETARY FAT Evolutionary Perspectives on Fat Ingestion and Metabolism in Humans, William R. Leonard, J. Josh Snodgrass, and Marcia L. Robertson Pathophysiology and Evolutionary AspectsExpand
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Human genetic polymorphisms in T1R1 and T1R3 taste receptor subunits affect their function.
Umami is the typical taste induced by monosodium glutamate (MSG), which is thought to be detected by the heterodimeric G protein-coupled receptor, T1R1 and T1R3. Previously, we showed that MSGExpand
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