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Norepinephrine-induced Ca2+waves depend on InsP3 and ryanodine receptor activation in vascular myocytes.
- F. Boittin, N. Macrez, G. Halet, J. Mironneau
- BiologyAmerican journal of physiology. Cell physiology
- 1 July 1999
Results show that ryanodine-sensitive Ca2+release channels are responsible for the fast propagation of Ca2- responses evoked by various neurotransmitters producing InsP3in vascular and visceral myocytes.
Activation of calcium sparks by angiotensin II in vascular myocytes.
- S. Arnaudeau, N. Macrez-Leprêtre, J. Mironneau
- BiologyBiochemical and biophysical research…
- 24 May 1996
It is shown that angiotensin AT1 receptors stimulate Ca2- sparks through activation of L-type Ca2+ channels without involving InsP3-induced Ca2+, suggesting this novel transduction pathway may be a common mechanism for vasoconstrictors which do not stimulate generation of chemical second messengers.
Ca2+ sparks and Ca2+ waves activate different Ca(2+)-dependent ion channels in single myocytes from rat portal vein.
Phosphoinositide 3-Kinase γ Mediates Angiotensin II-induced Stimulation of L-type Calcium Channels in Vascular Myocytes*
The results show that, although both PI3Kγ andPI3Kα are expressed in vascular myocytes, the angiotensin II-induced stimulation of vascular L-type calcium channel and increase of [Ca2+] i involves only the PI3kγ isoform.
Calcium-activated chloride current in rat vascular smooth muscle cells in short-term primary culture
- P. Pacaud, G. Loirand, J. Lavie, C. Mironneau, J. Mironneau
- BiologyPflügers Archiv - European Journal of Physiology
- 1 April 1989
The effect of compounds known to interfere with chloride channels together with the data on the equilibrium potential for chloride ions indicated above suggested the existence of a calcium-activated chloride current in vascular smooth muscle cells.
Ca(2+) signals mediated by Ins(1,4,5)P(3)-gated channels in rat ureteric myocytes.
- F. Boittin, F. Coussin, J. Morel, G. Halet, N. Macrez, J. Mironneau
- BiologyThe Biochemical journal
- 1 July 2000
Results suggest that Ins(1,4,5)P(3)-gated channels mediate a continuum of Ca(2+) signalling in smooth-muscle cells expressing a high level of Ins(2+)-overloaded myocytes and no subtypes 1 and 2 of ryanodine receptors.
A βγ Dimer Derived from G13 Transduces the Angiotensin AT1 Receptor Signal to Stimulation of Ca2+ Channels in Rat Portal Vein Myocytes*
- N. Macrez, J. Morel, F. Kalkbrenner, P. Viard, G. Schultz, J. Mironneau
- BiologyThe Journal of Biological Chemistry
- 12 September 1997
It is shown that activation of angiotensin AT1 receptors requires all three α, β, and γ subunits of G13 for receptor-G protein interaction, whereas the transduction of the signal to L-type Ca2+ channels is mediated by Gβγ.
G²γ dimers stimulate vascular L‐type Ca2+ channels via phosphoinositide 3‐kinase
- P. Viard, T. Exner, U. Maier, J. Mironneau, B. Nürnberg, N. Macrez
- BiologyFASEB journal : official publication of the…
- 1 April 1999
Results indicate for the first time that G²γ dimers stimulate the vascular L‐type Ca2+ channels through a G¬γ‐sensitive PI3K.
Phosphoinositide 3-Kinase Isoforms Selectively Couple Receptors to Vascular L-Type Ca2+ Channels
It is brought evidences that vascular L-type Ca2+ channels can be modulated by both tyrosine kinase–regulated class Ia and G protein-regulated class Ib PI3Ks and that different isoforms ofPI3K regulate physiological increases of Ca2- influx in vascular myocytes stimulated by vasoconstrictor or growth factor.
Crucial Role of Type 2 Inositol 1,4,5-Trisphosphate Receptors for Acetylcholine-Induced Ca2+ Oscillations in Vascular Myocytes
- J. Morel, Nicolas Fritz, J. Lavie, J. Mironneau
- BiologyArteriosclerosis, thrombosis, and vascular…
- 1 September 2003
The results suggest that in native smooth muscle cells, a differential expression of InsP3R subtypes encodes specific InsP 3-mediated Ca2+ responses and that the presence of the InsP2R2 subtype is required for acetylcholine-induced Ca2-induced oscillations in vascular myocytes.