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Genomic Structure of an Attenuated Quasi Species of HIV-1 from a Blood Transfusion Donor and Recipients
TLDR
Data show that survival after HIV infection can be determined by the HIV genome and support the importance of nef or the U3 region of the LTR in determining the pathogenicity of HIV-1. Expand
Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort.
TLDR
After prolonged infection with this attenuated strain of HIV-1, there is evidence of immunologic damage in three of the four subjects with detectable plasma HIV- 1 RNA and the CD4 lymphocyte counts appear to be stable in the three subjects in whom plasmaAIDS-1 RNA remains undetectable. Expand
Human immunodeficiency virus type 1 replication is blocked prior to reverse transcription and integration in freshly isolated peripheral blood monocytes
TLDR
The finding that in vitro replication of HIV-1 is clearly blocked prior to the initiation of reverse transcription in freshly isolated peripheral blood monocytes suggests that these cells may not be susceptible to infection in vivo. Expand
Human immunodeficiency virus type 1 Nef binds directly to Lck and mitogen-activated protein kinase, inhibiting kinase activity
TLDR
Binding and coprecipitation assays with short synthetic peptides corresponding to the proline-rich repeat sequence of Nef and the SH2, SH3, or SH2 and SH3 domains of Lck revealed that the interaction between these two proteins is at least in part mediated by the pro line repeat sequences of Nf and theSH3 domain of Lk. Expand
Acyclovir-resistant herpes simplex virus infections in patients with the acquired immunodeficiency syndrome.
TLDR
A small number of patients with the acquired immunodeficiency syndrome (AIDS) are diagnosed with HSV infection each year, and the virus can be passed on to their partners through contact chemoreception and sexual transmission. Expand
Association of Respiratory Syncytial Virus M Protein with Viral Nucleocapsids Is Mediated by the M2-1 Protein
TLDR
The data demonstrate for the first time that the M protein associates with cytoplasmic inclusions via an interaction with the M2-1 protein, which may represent a target for novel antivirals that block the association of M with nucleocapsids, thereby inhibiting virus assembly. Expand
Oral therapy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. A controlled trial of trimethoprim-sulfamethoxazole versus trimethoprim-dapsone.
TLDR
In patients with AIDS, oral therapy with trimethoprim-sulfamethoxazole and with trimetrim-dapsone are equally effective for mild-to-moderate first episodes of P. carinii pneumonia, but with trimmedethopim- dapsone there are fewer serious adverse reactions than with trimETHoprim. Expand
Experimental respiratory syncytial virus infection of adults. Possible mechanisms of resistance to infection and illness.
TLDR
Resistance to extensive infection in both studies, and resistance to illness in the second study, appeared to be correlated with high levels of nasal wash antibody, but not with the level of serum antibody. Expand
Respiratory syncytial virus matrix protein associates with nucleocapsids in infected cells.
TLDR
The data suggest that the M protein is associated with RSV nucleocapsids and, like the matrix proteins of other negative-strand RNA viruses, can inhibit virus transcription. Expand
The matrix protein of Human respiratory syncytial virus localises to the nucleus of infected cells and inhibits transcription
TLDR
The kinetics of localisation of matrix (M) protein of Human respiratory syncytial virus in infected cells suggests that M protein may play a role early in the infection by inhibiting host cell transcription. Expand
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