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Binding of ATP to Heat Shock Protein 90
TLDR
Results clearly demonstrate that hsp90 possesses a second ATP-binding site located on the C-terminal part of the protein and suggest allosteric interaction between N- and C-Terminal domains of hSp90. Expand
Drug-eluting beads for liver embolization: concentration of doxorubicin in tissue and in beads in a pig model.
TLDR
Doxorubicin-eluting beads deliver high concentrations of the drug over a period of at least 3 months at several hundred micrometers from the bead, leading to significant cytotoxic effects. Expand
Characterization of Acidic Vesicles in Multidrug-resistant and Sensitive Cancer Cells by Acridine Orange Staining and Confocal Microspectrofluorometry
TLDR
The data allow the hypothesis of a higher pH gradient through membranes of acidic organelles, which would be a potential mechanism of multidrug resistance via the sequestration of weak bases inside these organlles. Expand
Kinetics of lactone hydrolysis in antitumor drugs of camptothecin series as studied by fluorescence spectroscopy.
TLDR
To quantify in 'real time' the lactone hydrolysis reaction in CPTs under physiological conditions, a non-perturbing approach by fluorescence spectroscopy is applied, demonstrating that the spectroscopic approach provides a satisfactory precision for this kind of measurements. Expand
Doxorubicin-loaded nanospheres bypass tumor cell multidrug resistance.
TLDR
Dox, when loaded in nanospheres, bypasses the efflux mechanism responsible for multidrug resistance and interacts with DNA identically in sensitive and resistant cells. Expand
Characterisation of a navelbine-resistant bladder carcinoma cell line cross-resistant to taxoids.
TLDR
It is suggested that the mechanism of resistance of J82-NVB cells involves recovery from the inhibition of microtubule dynamics induced by drug treatment, which is not a classical MDR phenotype. Expand
Surface-enhanced Raman scattering reveals adsorption of mitoxantrone on plasma membrane of living cells.
TLDR
SERS spectroscopy could be a direct method to reveal drug adsorption to the membrane environment of living cells in the plasma membrane microenvironment of sensitive or BCRP/MXR-type resistant cells. Expand
Free and total magnesium in lymphocytes of migraine patients - effect of magnesium-rich mineral water intake.
TLDR
Among the analyzed parameters, Mg(2+) in lymphocytes appears to be the most sensitive index of magnesium deficiency with a 15% decrease in migraine patients when compared to controls and a 16% increase after 2 weeks of a magnesium-rich mineral water intake. Expand
Membrane potential changes after infection of monocytes by Toxoplasma gondii.
TLDR
This is the first report showing the presence of ion transporters in the T. gondii PVM and the existence of at least two members of the P-type family of ion pumps: an electrogenic H(+)ATPase and an electroneutral H(+)/K(+) ATPase. Expand
Oriented conjugates of single-domain antibodies and quantum dots: toward a new generation of ultrasmall diagnostic nanoprobes.
TLDR
The authors report the development of sdAbs-QD-oriented conjugates, comprised of single domain antibodies that are 12 times smaller than regular mAb-s and quantum dots that represent a new generation of ultrasmall diagnostic probes for applications in high-throughput diagnostic platforms. Expand
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