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Relationship between antithrombotic activities of fucans and their structure
A low molecular weight fucan fraction extracted from the brown seaweed Ascophyllum nodosum was previously shown to exhibit dose‐related venous antithrombotic activity with an ED80 of about 20 mg/kg,… Expand
Venous antithrombotic and anticoagulant activities of a fucoïdan fraction.
Fucoïdan extracted from marine flora shows promise as an antithrombotic drug in rabbits and in a Wessler model of venous thrombosis. Expand
Antithrombotic and anticoagulant activities of a low molecular weight fucoidan by the subcutaneous route.
LMW fucoidan has potent antithrombotic activity and a potentially weaker haemorrhagic effect (i.e. a smaller effect on coagulation tests and a smaller prolongation of the bleeding time) than dalteparin. Expand
A new experimental model of venous thrombosis in rats involving partial stasis and slight endothelium alterations.
Venous thrombus formation is induced in rats using saline flushing in a venous bag created in the vena cava and subsequent stasis by stricture of the vein and transmission electron microscopy demonstrated that flushing induces discrete endothelial lesions with no evident desendothelialisation areas. Expand
Effect of low‐molecular‐weight fucoidan on experimental arterial thrombosis in the rabbit and rat
- S. Colliec-Jouault, J. Millet, D. Helley, C. Sinquin, A. Fischer
- Journal of thrombosis and haemostasis : JTH
- 1 May 2003
was used to perform an extra-corporeal arteriovenous shunt between the carotid artery and the jugular vein and both fucoidan and unfractionated heparin inhibited thrombus formation significantly. Expand
The effect of the beta-D-xyloside naroparcil on circulating plasma glycosaminoglycans. An explanation for its known antithrombotic activity in the rabbit.
- P. Masson, D. Coup, J. Millet, N. Brown
- Chemistry, Biology
- The Journal of biological chemistry
- 10 February 1995
This is, to the authors' knowledge, the first description of the in vivo effect of a beta-D-xyloside on GAG biosynthesis and this is correlated with an antithrombotic action. Expand
Experimental venous thrombosis induced by homologous serum in the rat.
The purpose of the present study was to compare the activities of heterologous and homologous serum as hypercoagulating agents in a rat stasis model of venous thrombosis using Wessler's technique. Expand
The venous antithrombotic effect of LF 1351 in the rat following oral administration.
LF 1351 demonstrated a dose-related antithrombotic effect in three models of venous thrombosis and was approximately equipotent in two models involving complete stasis of the vena cava and administration of factor Xa or porcine serum. Expand
The venous antithrombotic profile of naroparcil in the rabbit.
The venous antithrombotic profile of naroparcil or (4-[4-cyanobenzoyl]-phenyl)-1.5-dithio-beta-D-xylopyranoside was investigated in the rabbit following single i.v. and oral administration and thrombin generation by the intrinsic pathway was reduced in a dose-related manner. Expand
The arterial antithrombotic activity of thioxylosides in a rat model of laser-induced thrombosis.
- O. Aguejouf, F. A. Oualane, +5 authors C. Doutremépuich
- Seminars in thrombosis and hemostasis
The data suggest that these beta-D xylosides are potent arterial antithrombotic agents after single or repetitive oral administrations, and constitute a very promising therapeutic class of orally active antithROMbotic drugs. Expand