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Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease.
Platelet-type von Willebrand disease (PT-vWD) is an autosomal dominant bleeding disorder characterized by abnormally enhanced binding of von Willebrand factor (vWF) by patient platelets. Although theExpand
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Pegylation of a chlorin(e6) polymer conjugate increases tumor targeting of photosensitizer.
Photodynamic therapy is emerging as a viable modality for the treatment of many cancers. A limiting factor in its use against intracavity tumors such as disseminated ovarian cancer is insufficientExpand
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Alterations in the intrinsic properties of the GPIbalpha-VWF tether bond define the kinetics of the platelet-type von Willebrand disease mutation, Gly233Val.
Platelet-type von Willebrand disease (PTVWD) is a bleeding disorder in which an increase of function mutation in glycoprotein Ibalpha (GPIbalpha), with respect to binding of von Willebrand factorExpand
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Mutation of leucine-57 to phenylalanine in a platelet glycoprotein Ib alpha leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard-Soulier disease.
The primary sequences of the three individual glycoprotein (GP) chains, GPIb alpha, GPIb beta, and GPIX, comprising the normal platelet GPIb/IX receptor for von Willebrand factor (vWF) have recentlyExpand
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Catalytic Hydrothermal Conversion of Triglycerides to Non-ester Biofuels
This paper describes a catalytic hydrothermolysis (CH) process aimed at converting triglycerides to non-ester biofuels. The CH conversion was carried out at temperatures ranging from 450 to 475 °CExpand
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Platelet-type von Willebrand disease.
  • J. Miller
  • Medicine
  • Thrombosis and haemostasis
  • 1 June 1996
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Modulation of metarhodopsin formation by cholesterol-induced ordering of bilayer lipids.
The effect of lipid ordering on the kinetics and extent of metarhodopsin II (meta II) formation was evaluated in bovine rhodopsin which had been reconstituted into phosphatidylcholine vesiclesExpand
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Plasmin inhibition of thrombin-induced platelet aggregation.
The effects of plasmin treatment upon washed human platelets were studied in an attempt to elucidate the mechanisms underlying thrombin-induced platelet aggregation. At calcium concentrations ofExpand
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von Willebrand factor binds to platelets and induces aggregation in platelet-type but not type IIB von Willebrand disease.
Platelet-type von Willebrand disease (vWD) and pseudo-vWD are two recently described intrinsic platelet defects characterized by enhanced ristocetin-induced agglutination in platelet-rich plasma. AExpand
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Combination photoimmunotherapy and cisplatin: effects on human ovarian cancer ex vivo.
BACKGROUND Patients with ovarian cancer that is clinically resistant to cisplatin-based chemotherapy have little hope of a cure of their disease. Photoimmunotherapy, which involves theExpand
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