• Publications
  • Influence
Importance of glial activation in neuropathic pain.
Glia plays a crucial role in the maintenance of neuronal homeostasis in the central nervous system. The microglial production of immune factors is believed to play an important role in nociceptiveExpand
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Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain.
Recent research has shown that microglial cells which are strongly activated in neuropathy can influence development of allodynia and hyperalgesia. Here we demonstrated that preemptive and repeatedExpand
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Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain.
The pharmacological attenuation of glial activation represents a novel approach for controlling neuropathic pain, but the role of microglial and astroglial cells is not well established. To betterExpand
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Modulation of microglia can attenuate neuropathic pain symptoms and enhance morphine effectiveness.
  • J. Mika
  • Medicine
  • Pharmacological reports : PR
  • 1 May 2008
Microglia play a crucial role in the maintenance of neuronal homeostasis in the central nervous system, and microglia production of immune factors is believed to play an important role in nociceptiveExpand
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Mechanisms and pharmacology of diabetic neuropathy - experimental and clinical studies.
Neuropathic pain is the most common chronic complication of diabetes mellitus. The mechanisms involved in the development of diabetic neuropathy include changes in the blood vessels that supply theExpand
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Antinociceptive effect of antisense oligonucleotides against the vanilloid receptor VR1/TRPV1
To examine the role of the vanilloid receptor TRPV1 in neuropathic pain, we assessed the effects of the receptor antagonist thioxo-BCTC and antisense oligonucleotides against the TRPV1 mRNA in a ratExpand
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Comparison of gene expression profiles in neuropathic and inflammatory pain.
Molecular mechanisms underlying the differences between chronic neuropathic and inflammatory pain are still poorly understood. Identifying those differences should provide insight into the molecularExpand
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Minocycline influences the anti-inflammatory interleukins and enhances the effectiveness of morphine under mice diabetic neuropathy
A single streptozotocin (STZ) injection in mice can induce significant neuropathic pain along with an increase in plasma glucose levels and a decrease in body weight. Seven days after theExpand
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Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats
Despite many advances, our understanding of the involvement of prodynorphin systems in the development of neuropathic pain is not fully understood. Recent studies suggest an important role ofExpand
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The role of delta-opioid receptor subtypes in neuropathic pain.
A large body of evidence suggests an important role of delta-opioid receptor agonists in antinociception at the level of the spinal cord. Our study was undertaken to analyse the spinalExpand
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