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Mechanisms of Chemotherapy-Induced Peripheral Neuropathy
- R. Zajączkowska, Magdalena Kocot-Kępska, W. Leppert, A. Wrzosek, J. Mika, J. Wordliczek
- MedicineInternational journal of molecular sciences
- 1 March 2019
A better understanding of the risk factors and underlying mechanisms of CIPN is needed to develop effective preventive and therapeutic strategies and the neurotoxicity mechanisms of the most common antineoplastic agents are reviewed.
Importance of glial activation in neuropathic pain.
Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain.
Differential activation of spinal microglial and astroglial cells in a mouse model of peripheral neuropathic pain.
Modulation of microglia can attenuate neuropathic pain symptoms and enhance morphine effectiveness.
- J. Mika
- BiologyPharmacological reports : PR
- 1 May 2008
The results of many studies support the idea that modulation of glial and neuroimmune activation may be a potential therapeutic mechanism for enhancement of morphine analgesia and targeting glial activation is a clinically promising method for treatment of neuropathic pain.
Mechanisms and pharmacology of diabetic neuropathy - experimental and clinical studies.
Spinal analgesic action of endomorphins in acute, inflammatory and neuropathic pain in rats.
Comparison of gene expression profiles in neuropathic and inflammatory pain.
- J. Rodriguez Parkitna, M. Korostyński, R. Przewłocki
- BiologyJournal of physiology and pharmacology : an…
- 1 September 2006
The data point at the importance of immune response- and microglia activation-related genes in the development of chronic neuropathic pain, and suggest that expression of CGRP gene in the dorsal horn of the spinal cord could be involved in persistence of its symptoms.
Antinociceptive effect of antisense oligonucleotides against the vanilloid receptor VR1/TRPV1
The role of delta-opioid receptor subtypes in neuropathic pain.
Results show an antiallodynic and antinociceptive action of DPDPE and deltorphin II at the spinal cord level, which suggests that both delta-opioid receptor subtypes play a similar role in neuropathic pain.