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Mutations in myosin heavy chain 11 cause a syndrome associating thoracic aortic aneurysm/aortic dissection and patent ductus arteriosus
TLDR
Human MYH11 gene mutations provide the first example of a direct change in a specific SMC protein leading to an inherited arterial disease. Expand
Angiotensin II stimulates endothelial vascular cell adhesion molecule-1 via nuclear factor-kappaB activation induced by intracellular oxidative stress.
TLDR
It is demonstrated that Ang II induced an intracellular oxidative stress in endothelial cells, which stimulates IkappaB degradation and nuclear factor-kappaB activation and enhances the expression of VCAM-1 and probably other genes involved in the early stages of atherosclerosis. Expand
The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles.
TLDR
The medial VSMC is the organizer of the inwardly directed angiogenic response arising from the adventitia by overexpressing vascular endothelial growth factor in response to lipid-stimulated peroxisome proliferator-activated receptor-γ, and probably also the organizers of the adventitial immune response by secreting chemokines. Expand
Involvement of the mural thrombus as a site of protease release and activation in human aortic aneurysms.
TLDR
This study strongly suggests that the mural thrombus, by trapping polymorphonuclear leukocytes and adsorbing plasma components could act as a source of proteases in aneurysms that may play a critical role in enlargement and rupture. Expand
Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans
TLDR
Abdominal aortic aneurysm thus represents an accessible spatiotemporal model of human atherothrombotic progression towards clinical events, the study of which should allow further understanding of its pathogenesis and the translation of pathogenic biological activities into diagnostic and therapeutic applications. Expand
Extracellular matrix remodelling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors.
TLDR
Evidence of inflammatory injury more severe in AS than in AR and involvement of mesenchymal cell response is provided, demonstrating the involvement of the MMP/TIMP system in ECM remodelling of both AS and AR. Expand
Elastase-induced experimental aneurysms in rats.
TLDR
The results suggest that the presence of elastase within the aortic media leads to aneurysm formation and that plasmin may enhanceElastase activity and aggravate the aneurYSmal lesion. Expand
Caraway and caper: potential anti-hyperglycaemic plants in diabetic rats.
TLDR
It is concluded that aqueous extracts of CC and CS exhibit a potent anti-hyperglycaemic activity in STZ rats without affecting basal plasma insulin concentrations. Expand
Topology of the fibrinolytic system within the mural thrombus of human abdominal aortic aneurysms
TLDR
The results suggest that the increased plasma concentrations of PAPs and D‐dimers found in AAA patients are related to mural thrombus proteolytic activity, thus explaining their known link with AAA progression. Expand
Mediators of neutrophil recruitment in human abdominal aortic aneurysms
TLDR
Results suggest that platelet-derived RANTES and neutrophil-derived IL-8 are involved in attracting neutrophils to the luminal layer of AAA ILT. Expand
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