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High-Throughput Transcriptome Profiling in Drug and Biomarker Discovery
Compared with the traditional RNA-seq, scRNA-seq has higher accuracy and efficiency, especially the single-cell level of gene expression pattern analysis can provide more information for drug and biomarker discovery, therefore, (sc)RNA- sequencing has broader application prospects, especially in the field of drug discovery.
Identification of novel and conserved microRNAs in Panax notoginseng roots by high-throughput sequencing
This study identified a large number of P. notoginseng miRNAs and their target genes, functional annotations, and gene expression patterns, and provides the first known miRNA profiles of the P.Notogineng root development cycle.
Prenylated isoflavones from Flemingia philippinensis
Two new prenylated isoflavones, named flemiphilippinins E and F, were isolated from the roots of Flemingia philippinensis, together with six known ones. The structures of the above compounds were
Cross-talk between Arg methylation and Ser phosphorylation modulates apoptosis signal–regulating kinase 1 activation in endothelial cells
Protein arginine methyltransferase 5 interacts with and methylates apoptosis signal–regulating kinase 1 at arginine residue 89, thereby negatively regulating its activity by promoting the interaction
Polyethylenimine-Mediated CpG Oligodeoxynucleotide Delivery Stimulates Bifurcated Cytokine Induction.
It is reported that polyethylenimine functions as a multifunctional vector for both enhancing and regulating the immunostimulatory activity of CpG ODNs, which will shed light on the development of highly efficient nonviral vectors for C pG ODN-based immunotherapy.
Transcriptome Analysis of Taxillusi chinensis (DC.) Danser Seeds in Response to Water Loss
This is the first time to profile transcriptome globally in loranthus seeds and indicates that HSPs and ribosomal proteins may function in early response to drought stress.