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Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells.
- Chuandong Fan, W. Wang, B. Zhao, S. Zhang, J. Miao
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 1 May 2006
To investigate the effects of chloroquine diphosphate (CQ) on lung cancer cell growth, we treated A549 cells, a lung cancer cell line, with the drug at various concentrations (0.25-128 microM) for… Expand
A new microRNA signal pathway regulated by long noncoding RNA TGFB2-OT1 in autophagy and inflammation of vascular endothelial cells
TGFB2-OT1 (TGFB2 overlapping transcript 1) is a newly discovered long noncoding RNA (lncRNA) derived from the 3′UTR of TGFB2. It can regulate autophagy in vascular endothelial cells (VECs). However,… Expand
An activator of mTOR inhibits oxLDL-induced autophagy and apoptosis in vascular endothelial cells and restricts atherosclerosis in apolipoprotein E-/- mice
Oxidized low-density lipoprotein (oxLDL) inhibits mammalian target of rapamycin (mTOR) and induces autophagy and apoptosis in vascular endothelial cells (VECs) that play very critical roles for the… Expand
Relationships between Alternaria alternata and oesophageal cancer.
Although it is uncertain whether fungi can produce the mycotoxins that induce oesophageal cancer, the tumorigenicity of fungi isolated from grain in an area of high incidence of oesophageal cancer… Expand
Identification of a novel MTOR activator and discovery of a competing endogenous RNA regulating autophagy in vascular endothelial cells
MTOR, a central regulator of autophagy, is involved in cancer and cardiovascular and neurological diseases. Modulating the MTOR signaling balance could be of great significance for numerous diseases.… Expand
Lipopolysaccharide induces autophagy through BIRC2 in human umbilical vein endothelial cells
Lipopolysaccharide (LPS), as an important proinflammatory agent, targets the endothelium. However, almost all in vitro experiments of the effect of LPS on vascular endothelial cells (VECs) were… Expand
Chronic restraint stress modulates expression of genes in murine spleen
- D. Yin, Y. Zhang, C. Stuart, J. Miao, M. Woodruff
- Biology, Medicine
- Journal of Neuroimmunology
- 1 August 2006
Psychological and physical stress can alter the immune system in both humans and animals. We have reported that mice subjected to chronic 12-h daily physical restraint for 2 days showed dramatic… Expand
HMBOX1 interacts with MT2A to regulate autophagy and apoptosis in vascular endothelial cells
We previously found that Homeobox containing 1 (HMBOX1) was required for bone mesenchymal stem cell (BMSC) and mouse embryonic stem cell (ESC) differentiation into vascular endothelial cells (VECs).… Expand
Discovery of a novel Nrf2 inhibitor that induces apoptosis of human acute myeloid leukemia cells
Nuclear factor-erythroid 2-related factor 2 (Nrf2) is persistently activated in many human tumors including acute myeloid leukemia (AML). Therefore, inhibition of Nrf2 activity may be a promising… Expand
Rattlesnake venom induces apoptosis by stimulating PC-PLC and upregulating the expression of integrin beta4, P53 in vascular endothelial cells.
- Q. Zhao, S. Araki, S. Zhang, J. Miao
- Biology, Medicine
- Toxicon : official journal of the International…
- 1 August 2004
In the previous studies, we found that phosphatidylcholine-specific phospholipase C (PC-PLC) was implicated in apoptosis induced by rattlesnake venom in vascular endothelial cells (VEC) [Biochem.… Expand