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COX-2 and PPAR-γ Confer Cannabidiol-Induced Apoptosis of Human Lung Cancer Cells
TLDR
In lung cancer cell lines and primary cells from a patient with lung cancer, cannabidiol elicited decreased viability associated with apoptosis and caused upregulation of COX-2 and PPAR-γ in tumor tissue and tumor regression that was reversible by GW9662. Expand
Decrease of Plasminogen Activator Inhibitor-1 May Contribute to the Anti-Invasive Action of Cannabidiol on Human Lung Cancer Cells
TLDR
Evidence for a hitherto unknown mechanism underlying the anti-invasive action of cannabidiol on human lung cancer cells is provided, suggesting a crucial role of PAI-1 in A549 invasiveness. Expand
Pancreatic fibrosis in experimental pancreatitis induced by dibutyltin dichloride.
TLDR
The findings suggest that dibutyltin dichloride-induced pancreatitis in rats is suitable to study cellular interactions and mediators involved in the development of pancreatic fibrosis. Expand
Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule‐1
TLDR
The data indicate that cannabinoids induce ICAM‐1, thereby conferring TIMP‐1 induction and subsequent decreased cancer cell invasiveness, and cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule‐1. Expand
Oxygen Radical Generation and Acute Pancreatitis: Effects of Dibutyltin Dichloride/Ethanol and Ethanol on Rat Pancreas
TLDR
A tissue imbalance between oxidants and antioxidants might be of importance in the pathogenesis of DBTCiEtOH-induced acute interstitial pancreatitis and although EtOH increases oxygen radical levels, additional damage is required for development of acute pancreatitis. Expand
The influence of ethanol on long-term effects of dibutyltin dichloride (DBTC) in pancreas and liver of rats
TLDR
Ethanol increased the toxic effects of DBTC on pancreas and liver during the acute and chronic course, and the significant increase of hydroxyproline in urine and hyaluronic acid in serum of the DBTC/ethanol treated rats after 12 to 24 weeks was connected with a more severe chronic inflammatory fibrosis in pancrea and liver in comparison to theDBTC-treated group. Expand
Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1.
TLDR
Findings provide a novel mechanism underlying the anti-invasive action of cannabidiol and imply its use as a therapeutic option for the treatment of highly invasive cancers. Expand
Cytokine mRNA Levels and Lymphocyte Infiltration in Pancreatic Tissue During Experimental Chronic Pancreatitis Induced by Dibutyltin Dichloride
TLDR
The results suggest that in experimental pancreatitis acute inflammatory reactions are followed by a T-lymphocyte-mediated process. Expand
Heat Shock Response is Associated with Protection Against Acute Interstitial Pancreatitis in Rats
TLDR
Hyperthermia preconditioning exerts protective effects against two pathophysiologically different types of pancreatitis by a mechanism that involves the up-regulation of HSP70 isoforms as well as TGF-β1. Expand
Fatty acid amide hydrolase inhibitors confer anti-invasive and antimetastatic effects on lung cancer cells
TLDR
The present study provides first-time proof for an antimetastatic action of FAAH inhibitors and a mechanism of its anti-invasive properties an upregulation of TIMP-1 was identified. Expand
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