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Detection and characterisation of swine hepatitis E virus in New Zealand
It was concluded that HEV is widely distributed in the New Zealand pig population, andylogenetic analysis shows that this is a new HEV strain, grouping most closely with the United States/European cluster, which includes HEV strains of both human and swine origin. Expand
Hepatitis E virus genotyping based on full-length genome and partial genomic regions.
It was demonstrated with both one- way ANOVA and two-way ANOVA that only one genomic region in RNA-dependent RNA polymerase domain (4254-4560nt) for which there were no significant differences when compared with the full-length genome (P>0.05) was identified. Expand
A new PCR-based seroneutralization assay in cell culture for diagnosis of hepatitis E.
A new method for the serological diagnosis of hepatitis E virus (HEV) infection based on neutralization of the virus in cell culture was developed and is proposed as a confirmatory test for the available enzyme-linked immunosorbent assay (ELISA), which is now recognized as giving many false-positive reactions. Expand
Restricted Enzooticity of Hepatitis E Virus Genotypes 1 to 4 in the United States
  • C. Dong, J. Meng, +20 authors C. Teo
  • Biology, Medicine
  • Journal of Clinical Microbiology
  • 12 October 2011
A serological assay with capability to detect anti-HEV-antibody across a wide variety of animal species was devised, and the role of other animals as reservoirs of its zoonotic spread appears to be limited. Expand
Primary structure of open reading frame 2 and 3 of the hepatitis E virus isolated from Morocco
The nucleotide sequence from position 5,014 to 7,186 of the hepatitis E virus (HEV) genome was determined using a set of 10 polymerase chain reaction (PCR) fragments amplified directly from a pool ofExpand
Identification and characterization of the neutralization epitope(s) of the hepatitis E virus.
It is established for the first time that the minimal size fragment, designated pB166, that can efficiently model the neutralization epitope(s) of the hepatitis E virus is 166 aa in length and is located at position 452-617 aa of the HEV pORF2. Expand
Rabbit as a Novel Animal Model for Hepatitis E Virus Infection and Vaccine Evaluation
Rabbits may be served as an alternative to the non-human primate models for HEV infection and vaccine evaluation when certain virus strains, appropriate viral dosages, and the intravenous route of inoculation are selected. Expand
Serologic assays specific to immunoglobulin M antibodies against hepatitis E virus: pangenotypic evaluation of performances.
Six immunoassays for detecting immunoglobulin M antibodies to hepatitis E virus were evaluated and two of them were found to be particularly disparate. Expand
Identification of genetic diversity of hepatitis E virus (HEV) and determination of the seroprevalence of HEV in eastern China
25 HEV strains, isolated from sporadic hepatitis E cases in eastern China, were sequenced in the RNA-dependent RNA polymerase region and subjected to phylogenetic analysis, revealing most of them formed new sub-genotypes and revealed a high degree of genetic variance. Expand
Seroprevalence of Hepatitis E Virus Varies Considerably Among Chinese Provinces
HEV prevalence varies considerably among Chinese provinces and in the people from different ethnic minorities, and the results showed that the anti-HEV IgG detection rates increased with age for each ethnic group. Expand