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Subjective and hormonal effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans
AbstractRationale. 3,4-Methylenedioxymethamphetamine (MDMA) is a widely used phenethylamine. Reports have described the effects of MDMA in a controlled laboratory setting, but the full range ofExpand
Use patterns and self-reported effects of Salvia divinorum: an internet-based survey.
BACKGROUND There is growing use of Salvia divinorum (SD), a psychoactive plant that produces hallucinogen-like effects through a kappa opioid receptor (KOR) mechanism. Little is known about KORExpand
The bioavailability of intranasal and smoked methamphetamine
Patients in harm‐reduction treatment programs are switching from intravenous to otherroutes of methamphetamine (INN, metamfetamine) administration to avoid risks associated with needle use.Expand
Human Pharmacology of the methamphetamine stereoisomers
To help predict the consequences of precursor regulation, we compared the pharmacokinetics and pharmacodynamics of the methamphetamine (INN, metamfetamine) stereoisomers.
Methamphetamine and ethanol interactions in humans
Methamphetamine and ethanol are commonly used together. We examined the effects of intravenous methamphetamine (30 mg), oral ethanol (1 gm/kg), and the combination of methamphetamine (30 mg) andExpand
The pharmacology of cocaethylene in humans following cocaine and ethanol administration.
BACKGROUND Concurrent use of cocaine and alcohol results in formation of a cocaine homolog and metabolite-cocaethylene. METHODS To characterize cocaethylene pharmacology, ten paid volunteerExpand
Bioavailability of Sublingual Buprenorphine
Buprenorphine administered sublingually is a promising treatment for opiate dependence. Utilizing a new, sensitive, and specific gas chromatographic electron‐capture detector assay, the absoluteExpand
Buprenorphine and naloxone co-administration in opiate-dependent patients stabilized on sublingual buprenorphine.
Buprenorphine and naloxone sublingual (s.l.) dose formulations may decrease parenteral buprenorphine abuse. We evaluated pharmacologic interactions between 8 mg s.l. buprenorphine combined with 0, 4,Expand
Buprenorphine Pharmacokinetics: Relative Bioavailability of Sublingual Tablet and Liquid Formulations
Buprenorphine is an effective new treatment for opiate dependence. This study compared the bioavailability of buprenorphine from a tablet to that from a reference solution. Six men experienced with,Expand
Stereoselectivity in the human metabolism of methamphetamine.
AIM To characterize the formation and urinary elimination of metabolites of S-(+) and R-(-) methamphetamine (MA) in humans. METHODS In this 12-subject, six-session, double-blind,Expand