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The Natural History of Alcoholism Revisited
In 1983 Dr George Vaillant reported a study, The Natural History of Alcoholism , based upon a research program of adult development at the Harvard Medical School. The original study carried out fromExpand
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Age-related Reduction in Functional MRI Response to Photic Stimulation
Many functional imaging studies have demonstrated age-related alterations in cerebral blood flow during the resting state. However, few studies have addressed possible differences in functionalExpand
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Hyponatremia in marathon runners due to inappropriate arginine vasopressin secretion.
PURPOSE Exercise-associated hyponatremia (EAH), as defined by a blood sodium concentration [Na+] less than 135 mmol/L, may lead to hypotonic encephalopathy with fatal cerebral edema. UnderstandingExpand
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Buprenorphine suppresses heroin use by heroin addicts.
Heroin-dependent men were given buprenorphine (a partial opiate agonist-antagonist) or a placebo under duoble-blind conditions on a clinical research ward where they could acquire heroin (21 to 40.5Expand
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Sex differences in plasma cocaine levels and subjective effects after acute cocaine administration in human volunteers
Gender differences after acute cocaine administration have received little attention in spite of the fact that males and females respond differently to many drugs. Seven male and seven femaleExpand
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Cocaine’s Effects on Neuroendocrine Systems: Clinical and Preclinical Studies
This review examines the effects of cocaine on the neuroendocrine system and summarizes findings from clinical studies of cocaine abusers and preclinical studies in rodents and rhesus monkeys. TheExpand
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EEG alpha activity increases during transient episodes of ethanol-induced euphoria
The effects of acute ethanol administration were studied in 18 men to determine the electroencephalographic (EEG) correlates of ethanol-induced behavioral changes. Subjects were instructed to operateExpand
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Buprenorphine effects on human heroin self-administration: an operant analysis.
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Cocaine Pharmacokinetics in Men and in Women During the Follicular and Luteal Phases of the Menstrual Cycle
Preclinical and clinical studies suggest that females may be less vulnerable to cocaine's toxic effects than males. The pharmacokinetics of intravenous cocaine (0.2 and 0.4 mg/kg) were measured in 12Expand
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Management of cocaine abuse and dependence.
During the 20th century, there have been recurrent episodes of cocaine abuse in the United States that have achieved epidemic proportions.1 Although the total number of people using the drug hasExpand
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