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Anxiogenic stimuli in the elevated plus-maze
Untreated rats normally avoid the open arms of the "elevated plus-maze," preferring instead the closed arms, whereas rats treated with antianxiety drugs (e.g., diazepam) show far less open-armExpand
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Effects of centrally administered anxiolytic compounds in animal models of anxiety
  • J. Menard, D. Treit
  • Psychology, Medicine
  • Neuroscience & Biobehavioral Reviews
  • 1 March 1999
The effect of intra-cerebrally infused compounds in animal models of anxiety were reviewed. A large body of evidence suggested that benzodiazepine agonists in different brain regions--including areasExpand
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Repeated exposure to stress across the childhood-adolescent period alters rats' anxiety- and depression-like behaviors in adulthood: The importance of stressor type and gender.
This research tests the hypothesis that specific forms of adversity in early life map onto behavioral signs analogous to depression versus anxiety in later life. Male and female rats were exposed toExpand
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The anxiolytic effects of intra-hippocampal midazolam are antagonized by intra-septal l-glutamate
According to Gray [The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-hippocampal System, Oxford University Press, New York, 1982], the hippocampus and the septum act inExpand
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Lateral and medial septal lesions reduce anxiety in the plus-maze and probe-burying tests
Previous studies have shown that septal lesions produce anxiolytic-like effects in rat models of "anxiety" (i.e., septal lesions, like anxiolytic drugs, increase rats' open-arm exploration in theExpand
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Behavioral anxiolysis without reduction of hippocampal theta frequency after histamine application in the lateral septum of rats
Hippocampal theta activity is linked to various processes, including locomotion, learning and memory, and defense and affect (i.e., fear and anxiety). Interestingly, all classes of clinicallyExpand
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Variations of maternal care differentially influence ‘fear’ reactivity and regional patterns of cFos immunoreactivity in response to the shock-probe burying test
Natural variations in maternal care in the rat influence the development of neuronal systems that regulate endocrine and behavioral responses to stress. Thus, as adults, rats that received higherExpand
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Variations of maternal care alter offspring levels of behavioural defensiveness in adulthood: Evidence for a threshold model
Natural variations of maternal care in the rat influence the development of neuronal systems that regulate defensive responses to threat. Thus, as adults, rats that received higher levels of maternalExpand
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Post-weaning social isolation increases activity in a novel environment but decreases defensive burying and subchronic MK-801 enhances the activity but not the burying effect in rats
Subchronic treatment with a non-competitive glutamate NMDA-receptor antagonist [e.g., MK-801 or phencyclidine] or social isolation (SI) from weaning (age 21 days) to adulthood (age 56 days) produceExpand
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The lateral septum as a regulator of hippocampal theta oscillations and defensive behavior in rats.
Hippocampal theta oscillations are linked to various processes, including locomotion, learning and memory, and defense and affect. The lateral septum (LS) has been implicated in the generation of theExpand
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