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- Publications
- Influence
Anxiogenic stimuli in the elevated plus-maze
- D. Treit, J. Menard, Cary Royan
- Psychology, Medicine
- Pharmacology Biochemistry and Behavior
- 1 February 1993
Untreated rats normally avoid the open arms of the "elevated plus-maze," preferring instead the closed arms, whereas rats treated with antianxiety drugs (e.g., diazepam) show far less open-arm… Expand
Effects of centrally administered anxiolytic compounds in animal models of anxiety
The effect of intra-cerebrally infused compounds in animal models of anxiety were reviewed. A large body of evidence suggested that benzodiazepine agonists in different brain regions--including areas… Expand
Repeated exposure to stress across the childhood-adolescent period alters rats' anxiety- and depression-like behaviors in adulthood: The importance of stressor type and gender.
- J. Pohl, M. C. Olmstead, K. Wynne-Edwards, K. Harkness, J. Menard
- Psychology, Medicine
- Behavioral neuroscience
- 1 June 2007
This research tests the hypothesis that specific forms of adversity in early life map onto behavioral signs analogous to depression versus anxiety in later life. Male and female rats were exposed to… Expand
The anxiolytic effects of intra-hippocampal midazolam are antagonized by intra-septal l-glutamate
According to Gray [The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-hippocampal System, Oxford University Press, New York, 1982], the hippocampus and the septum act in… Expand
Lateral and medial septal lesions reduce anxiety in the plus-maze and probe-burying tests
Previous studies have shown that septal lesions produce anxiolytic-like effects in rat models of "anxiety" (i.e., septal lesions, like anxiolytic drugs, increase rats' open-arm exploration in the… Expand
Behavioral anxiolysis without reduction of hippocampal theta frequency after histamine application in the lateral septum of rats
- S. A. Chee, J. Menard, H. Dringenberg
- Psychology, Medicine
- Hippocampus
- 1 June 2014
Hippocampal theta activity is linked to various processes, including locomotion, learning and memory, and defense and affect (i.e., fear and anxiety). Interestingly, all classes of clinically… Expand
Variations of maternal care differentially influence ‘fear’ reactivity and regional patterns of cFos immunoreactivity in response to the shock-probe burying test
- J. Menard, D. Champagne, M. Meaney
- Psychology, Medicine
- Neuroscience
- 31 December 2004
Natural variations in maternal care in the rat influence the development of neuronal systems that regulate endocrine and behavioral responses to stress. Thus, as adults, rats that received higher… Expand
Variations of maternal care alter offspring levels of behavioural defensiveness in adulthood: Evidence for a threshold model
- J. Menard, R. Hakvoort
- Psychology, Medicine
- Behavioural Brain Research
- 25 January 2007
Natural variations of maternal care in the rat influence the development of neuronal systems that regulate defensive responses to threat. Thus, as adults, rats that received higher levels of maternal… Expand
Post-weaning social isolation increases activity in a novel environment but decreases defensive burying and subchronic MK-801 enhances the activity but not the burying effect in rats
- Sarah M. Simpson, J. Menard, J. Reynolds, R. Beninger
- Psychology, Medicine
- Pharmacology Biochemistry and Behavior
- 1 March 2010
Subchronic treatment with a non-competitive glutamate NMDA-receptor antagonist [e.g., MK-801 or phencyclidine] or social isolation (SI) from weaning (age 21 days) to adulthood (age 56 days) produce… Expand
The lateral septum as a regulator of hippocampal theta oscillations and defensive behavior in rats.
- S. A. Chee, J. Menard, H. Dringenberg
- Psychology, Medicine
- Journal of neurophysiology
- 15 March 2015
Hippocampal theta oscillations are linked to various processes, including locomotion, learning and memory, and defense and affect. The lateral septum (LS) has been implicated in the generation of the… Expand