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- Publications
- Influence
Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats.
- R. Bernabeu, L. Bevilaqua, +5 authors J. Medina
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 24 June 1997
cAMP/cAMP-dependent protein kinase (PKA) signaling pathway has been recently proposed to participate in both the late phase of long term potentiation in the hippocampus and in the late, protein… Expand
Persistence of Long-Term Memory Storage Requires a Late Protein Synthesis- and BDNF- Dependent Phase in the Hippocampus
- P. Bekinschtein, M. Cammarota, L. M. Igaz, Lia R. M. Bevilaqua, I. Izquierdo, J. Medina
- Psychology, Medicine
- Neuron
- 18 January 2007
Persistence is the most characteristic attribute of long-term memory (LTM). To understand LTM, we must understand how memory traces persist over time despite the short-lived nature and rapid turnover… Expand
Dopamine Controls Persistence of Long-Term Memory Storage
- J. Rossato, L. Bevilaqua, I. Izquierdo, J. Medina, M. Cammarota
- Biology, Medicine
- Science
- 21 August 2009
Making Memories Last How can memory traces persist over days or weeks, despite the short-lived nature and rapid turnover of their molecular substrates? It has recently been reported that, in order to… Expand
BDNF is essential to promote persistence of long-term memory storage
- P. Bekinschtein, M. Cammarota, +5 authors J. Medina
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 19 February 2008
Persistence is a characteristic attribute of long-term memories (LTMs). However, little is known about the molecular mechanisms that mediate this process. We recently showed that persistence of LTM… Expand
Memory Formation: The Sequence of Biochemical Events in the Hippocampus and Its Connection to Activity in Other Brain Structures
- I. Izquierdo, J. Medina
- Psychology, Medicine
- Neurobiology of Learning and Memory
- 1 November 1997
Recent data have demonstrated a biochemical sequence of events in the rat hippocampus that is necessary for memory formation of inhibitory avoidance behavior. The sequence initially involves the… Expand
Two Time Periods of Hippocampal mRNA Synthesis Are Required for Memory Consolidation of Fear-Motivated Learning
- L. M. Igaz, M. Vianna, J. Medina, I. Izquierdo
- Psychology, Medicine
- The Journal of Neuroscience
- 1 August 2002
Information storage in the brain is a temporally graded process involving different memory types or phases. It has been assumed for over a century that one or more short-term memory (STM) processes… Expand
On the role of hippocampal protein synthesis in the consolidation and reconsolidation of object recognition memory.
- J. Rossato, L. Bevilaqua, J. Myskiw, J. Medina, I. Izquierdo, M. Cammarota
- Psychology, Medicine
- Learning & memory
- 2007
Upon retrieval, consolidated memories are again rendered vulnerable to the action of metabolic blockers, notably protein synthesis inhibitors. This has led to the hypothesis that memories are… Expand
BDNF Activates mTOR to Regulate GluR1 Expression Required for Memory Formation
- L. Slipczuk, P. Bekinschtein, C. Katche, M. Cammarota, I. Izquierdo, J. Medina
- Biology, Medicine
- PloS one
- 23 June 2009
Background The mammalian target of Rapamycin (mTOR) kinase plays a key role in translational control of a subset of mRNAs through regulation of its initiation step. In neurons, mTOR is present at the… Expand
Separate mechanisms for short- and long-term memory
- I. Izquierdo, J. Medina, M. Vianna, L. Izquierdo, D. Barros
- Psychology, Medicine
- Behavioural Brain Research
- 1 August 1999
It has been assumed for over a century that short-term memory (STM) processes are in charge of cognition while long-term memory (LTM) is being formed, a process that takes hours. A major question is… Expand
Learning-associated activation of nuclear MAPK, CREB and Elk-1, along with Fos production, in the rat hippocampus after a one-trial avoidance learning: abolition by NMDA receptor blockade.
- M. Cammarota, L. Bevilaqua, +4 authors J. Medina
- Biology, Medicine
- Brain research. Molecular brain research
- 10 March 2000
It is widely accepted that the formation of long-term memory (LTM) requires neuronal gene expression, protein synthesis and the remodeling of synaptic contacts. From mollusk to mammals, the… Expand