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Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats.
- R. Bernabeu, L. Bevilaqua, J. Medina
- Biology, PsychologyProceedings of the National Academy of Sciences…
- 24 June 1997
It is reported that a late memory consolidation phase of an inhibitory avoidance learning is regulated by an hippocampal cAMP signaling pathway that is activated, at least in part, by D1/D5 receptors.
Persistence of Long-Term Memory Storage Requires a Late Protein Synthesis- and BDNF- Dependent Phase in the Hippocampus
Dopamine Controls Persistence of Long-Term Memory Storage
- J. I. Rossato, L. Bevilaqua, I. Izquierdo, J. Medina, M. Cammarota
- Biology, PsychologyScience
- 21 August 2009
The persistence of LTM depends on activation of VTA/hippocampus dopaminergic connections and can be specifically modulated by manipulating this system at definite post-learning time points.
BDNF is essential to promote persistence of long-term memory storage
- P. Bekinschtein, M. Cammarota, J. Medina
- Biology, PsychologyProceedings of the National Academy of Sciences
- 19 February 2008
It is demonstrated that intrahippocampal delivery of BDNF reverses the deficit in memory persistence caused by inhibition of hippocampal protein synthesis, and induces memory persistence by itself, transforming a nonlasting LTM trace into a persistent one in an ERK-dependent manner.
Two Time Periods of Hippocampal mRNA Synthesis Are Required for Memory Consolidation of Fear-Motivated Learning
It is shown that LTM formation of a one-trial inhibitory avoidance training in rats, a hippocampal-dependent form of contextual fear conditioning, depends on two consolidation periods requiring synthesis of new mRNAs, and suggests that the two time periods of anisomycin-induced amnesia depend at least in part on new mRNA synthesis.
Different molecular cascades in different sites of the brain control memory consolidation
The ubiquitin–proteasome cascade is required for mammalian long‐term memory formation
- Mariella Lopez‐Salon, M. Alonso, J. Medina
- BiologyThe European journal of neuroscience
- 1 December 2001
It is shown that the hippocampal blockade of this proteolytic pathway is also required for the formation of long‐term memory in the rat, indicating that the ubiquitin–proteasome cascade is crucial for the establishment of LTM in the behaving animal.
Mnemotechnics in Second-Language Learning
For some time I have been involved in efforts to develop computer-controlled systems for instruction. One such effort has been a computer-assistedinstruction (CAI) program for teaching reading in the…
Memory Formation: The Sequence of Biochemical Events in the Hippocampus and Its Connection to Activity in Other Brain Structures
It is suggested that the hippocampal chain of events that underlies memory formation is linked to long-term storage elsewhere through activity-dependent changes in cell connectivity.
ERK1/2 activation is necessary for BDNF to increase dendritic spine density in hippocampal CA1 pyramidal neurons.
The hypothesis that the ERK-signaling pathway not only mediates long-term synaptic plasticity and hippocampal-dependent learning, but it is also involved in the structural remodeling of excitatory spine synapses triggered by neurotrophins is supported.