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Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo.
- Daniel R. Clayburgh, T. Barrett, +6 authors J. Turner
- Medicine, Biology
- The Journal of clinical investigation
- 3 October 2005
Disruption of the intestinal epithelial barrier occurs in many intestinal diseases, but neither the mechanisms nor the contribution of barrier dysfunction to disease pathogenesis have been defined.… Expand
Discrimination of site-specific alterations in gastrointestinal permeability in the rat.
BACKGROUND & AIMS Detection of gastrointestinal damage can be accomplished by permeability testing. However, current methodology presents several problems, including lack of site specificity and an… Expand
Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis.
BACKGROUND & AIMS Inflammatory bowel disease (IBD) is a multifactorial disease thought to be caused by alterations in epithelial function, innate and adaptive immunity, and luminal microbiota. The… Expand
Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients.
- C. Doig, L. Sutherland, J. Sandham, G. Fick, M. Verhoef, J. Meddings
- American journal of respiratory and critical care…
- 1 August 1998
We conducted a prospective, observational cohort study designed to compare intestinal permeability (IP) and development of multiple organ dysfunction syndrome (MODS) in a subset of critically ill… Expand
Sucrose: a novel permeability marker for gastroduodenal disease.
BACKGROUND Nonsteroidal anti-inflammatory agents (NSAIDs) commonly cause asymptomatic gastroduodenal damage that may be clinically severe. At present the only method to determine the presence or… Expand
Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat.
BACKGROUND & AIMS Abnormal presentation of luminal constituents to the mucosal immune system, caused by dysfunction of the intestinal epithelial barrier, is a candidate theory for the cause of… Expand
A key claudin extracellular loop domain is critical for epithelial barrier integrity.
- R. J. Mrsny, G. T. Brown, +5 authors A. Nusrat
- Biology, Medicine
- The American journal of pathology
- 1 April 2008
Intercellular tight junctions (TJs) regulate epithelial barrier properties. Claudins are major structural constituents of TJs and belong to a large family of tetra-spanning membrane proteins that… Expand
Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat.
- J. Meddings, J. Jarand, S. Urbanski, J. Hardin, D. G. Gall
- American journal of physiology. Gastrointestinal…
- 1 April 1999
The BB rat spontaneously develops autoimmune diabetes. Feeding these animals a hydrolyzed casein diet significantly reduces the incidence of this disease, suggesting that a dietary antigen is… Expand
Analysis and comparison of sigmoidal curves: application to dose-response data.
A number of physiological or pharmacological studies generate sigmoidal dose-response curves. Ideally, data analysis should provide numerical solutions for curve parameters. In addition, for curves… Expand
GLP-2 augments the adaptive response to massive intestinal resection in rat
Scott, R. B., D. Kirk, W. K. MacNaughton, and J. B. Meddings. GLP-2 augments the adaptive response to massive intestinal resection in rat. Am. J. Physiol. 275 (Gastrointest. Liver Physiol. 38):… Expand