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Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo.
Disruption of the intestinal epithelial barrier occurs in many intestinal diseases, but neither the mechanisms nor the contribution of barrier dysfunction to disease pathogenesis have been defined.Expand
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Discrimination of site-specific alterations in gastrointestinal permeability in the rat.
BACKGROUND & AIMS Detection of gastrointestinal damage can be accomplished by permeability testing. However, current methodology presents several problems, including lack of site specificity and anExpand
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Targeted epithelial tight junction dysfunction causes immune activation and contributes to development of experimental colitis.
BACKGROUND & AIMS Inflammatory bowel disease (IBD) is a multifactorial disease thought to be caused by alterations in epithelial function, innate and adaptive immunity, and luminal microbiota. TheExpand
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Increased intestinal permeability is associated with the development of multiple organ dysfunction syndrome in critically ill ICU patients.
We conducted a prospective, observational cohort study designed to compare intestinal permeability (IP) and development of multiple organ dysfunction syndrome (MODS) in a subset of critically illExpand
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Sucrose: a novel permeability marker for gastroduodenal disease.
BACKGROUND Nonsteroidal anti-inflammatory agents (NSAIDs) commonly cause asymptomatic gastroduodenal damage that may be clinically severe. At present the only method to determine the presence orExpand
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Environmental stress-induced gastrointestinal permeability is mediated by endogenous glucocorticoids in the rat.
BACKGROUND & AIMS Abnormal presentation of luminal constituents to the mucosal immune system, caused by dysfunction of the intestinal epithelial barrier, is a candidate theory for the cause ofExpand
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A key claudin extracellular loop domain is critical for epithelial barrier integrity.
Intercellular tight junctions (TJs) regulate epithelial barrier properties. Claudins are major structural constituents of TJs and belong to a large family of tetra-spanning membrane proteins thatExpand
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Increased gastrointestinal permeability is an early lesion in the spontaneously diabetic BB rat.
The BB rat spontaneously develops autoimmune diabetes. Feeding these animals a hydrolyzed casein diet significantly reduces the incidence of this disease, suggesting that a dietary antigen isExpand
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Analysis and comparison of sigmoidal curves: application to dose-response data.
A number of physiological or pharmacological studies generate sigmoidal dose-response curves. Ideally, data analysis should provide numerical solutions for curve parameters. In addition, for curvesExpand
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GLP-2 augments the adaptive response to massive intestinal resection in rat
Scott, R. B., D. Kirk, W. K. MacNaughton, and J. B. Meddings. GLP-2 augments the adaptive response to massive intestinal resection in rat. Am. J. Physiol. 275 (Gastrointest. Liver Physiol. 38):Expand
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