Klebsiella pneumoniae: Going on the Offense with a Strong Defense
Recent studies have identified additional K. pneumoniae virulence factors and led to more insights about factors important for the growth of this pathogen at a variety of tissue sites, but much work is left to be done in characterizing these newly discovered factors.
Bacterial Secretion Systems: An Overview.
This chapter reviews the canonical features of several common bacterial protein secretion systems, as well as their roles in promoting the virulence of bacterial pathogens, and addresses recent findings that indicate that the innate immune system of the host can detect and respond to the presence ofprotein secretion systems during mammalian infection.
The activity of sigma E, an Escherichia coli heat-inducible sigma-factor, is modulated by expression of outer membrane proteins.
It is proposed that the sigma E regulon is involved in processes that occur in extracytoplasmic compartments and that these two heat-inducible regulons may have distinct but complementary roles of monitoring the state of proteins in the cy toplasm and outer membrane.
Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death.
- D. Monack, J. Mecsas, N. Ghori, S. Falkow
- BiologyProceedings of the National Academy of Sciences…
- 16 September 1997
The ability of Y. pseudotuberculosis to promote apoptosis of macrophages in cell culture suggests that this process is important for the establishment of infection in the host and for evasion of the host immune response.
Neutrophils to the ROScue: Mechanisms of NADPH Oxidase Activation and Bacterial Resistance
- G. T. Nguyen, Erin R Green, J. Mecsas
- BiologyFrontiers in Cellular and Infection Microbiology
- 25 August 2017
Mechanisms of oxidative burst in PMNs in response to bacterial infections, as well as the mechanisms by which bacterial pathogens thwart restriction by ROS to survive under conditions of oxidative stress are reviewed.
Requirement of the Yersinia pseudotuberculosis Effectors YopH and YopE in Colonization and Persistence in Intestinal and Lymph Tissues
While no single Yop was found to be essential for colonization or persistence in intestinal tissues in single-strain infections, the absence of both YopH and YopE together almost eliminated colonization of all tissues, indicating either that these two Yops have some redundant functions or that Y. pseudotuberculosis employs multiple strategies for colonization.
The C-Terminal Tail of Yersinia pseudotuberculosis YopM Is Critical for Interacting with RSK1 and for Virulence
A systematic deletion analysis of YopM in Yersinia pseudotuberculosis determined which regions are required for RSK1 interactions, nuclear localization, virulence, and changes in immune cell populations during infection of mice.
Yersinia-induced Apoptosis In Vivo Aids in the Establishment of a Systemic Infection of Mice
- D. Monack, J. Mecsas, D. Bouley, S. Falkow
- Biology, MedicineJournal of Experimental Medicine
- 7 December 1998
It is concluded that YopJ plays a role in the establishment of a systemic infection by inducing apoptosis and that this is consistent with the ability to suppress the production of the proinflammatory cytokine tumor necrosis factor α.
rpoE, the gene encoding the second heat‐shock sigma factor, sigma E, in Escherichia coli.
It is suggested that a gene encoding a negative regulator of sigma E activity is located immediately downstream of rpoE and may function as the target of the E s Sigma E inducing signal.
The presence of professional phagocytes dictates the number of host cells targeted for Yop translocation during infection
- Enrique Durand, Francisco J. Maldonado-Arocho, C. Castillo, Rebecca L. Walsh, J. Mecsas
- Biology, MedicineCellular Microbiology
- 1 August 2010
In the absence of neutrophils, the number of cells with translocated Yops was significantly reduced although the bacterial loads were similar, indicating that Y. pseudotuberculosis discriminates among cells it encounters during infection and selectively delivers Yops to phagocytes while refraining from translocation to other cell types.