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Imaging matrix metalloproteinases in cancer
This review draws attention to a variety of strategies utilized to image MMP activity in vivo, which target MMPs involved in cancer progression via contrast agents linked to MMPIs or to M MP selective and specific substrates with sensitivity enhanced by amplification during enzymatic processing.
Development of a novel fluorogenic proteolytic beacon for in vivo detection and imaging of tumour-associated matrix metalloproteinase-7 activity.
In vivo detection and imaging of tumour-associated MMP-7 activity using a novel polymer-based fluorogenic substrate PB-M7VIS, which serves as a selective 'proteolytic beacon' (PB) for this metalloproteinase.
Increased Diacylglycerols Characterize Hepatic Lipid Changes in Progression of Human Nonalcoholic Fatty Liver Disease; Comparison to a Murine Model
It was determined that mice maintained on a high-fat diet provide a reproducible model of NAFLD in regards to specificity of lipid species in the liver and these studies demonstrated that novel lipid species may serve as markers of advanced liver disease and importantly, marked increases in DAG species are a hallmark ofNAFLD.
Optical Imaging of Matrix Metalloproteinase-7 Activity in Vivo Using a Proteolytic Nanobeacon
- Randy L. Scherer, M. VanSaun, J. Mcintyre, L. Matrisian
- Biology, ChemistryMolecular imaging
- 1 May 2008
In vivo detection and quantitation of MMP7 activity using a specific near-infrared polymer-based proteolytic beacon, PB-M7NIR, and ex vivo imaging of intestines of multiple intestinal neoplasia revealed a sixfold increase in the sensor to reference ratio in the adenomas of APCMin mice.
4‐Hydroxy‐2(E)‐Nonenal Inhibits CNS Mitochondrial Respiration at Multiple Sites
- M. Picklo, V. Amarnath, J. Mcintyre, D. Graham, T. Montine
- Biology, ChemistryJournal of neurochemistry
- 1 April 1999
In neurodegenerative disease, oxidative stress may impair mitochondrial respiration through the production of 4‐hydroxy‐2(E)‐nonenal (HNE), a lipophilic alkenal that forms stable adducts on mitochondrial proteins.
Molecular imaging of proteolytic activity in cancer
This review describes key proteinases important in cancer progression, the strategies that have been devised to detect and image proteolytic activity in vivo, and the potential for this kind of functional imaging to serve as a marker for targeted therapy.
IL-13 and TH2 cytokine exposure triggers matrix metalloproteinase 7-mediated Fas ligand cleavage from bronchial epithelial cells.
Selective visualization of cyclooxygenase-2 in inflammation and cancer by targeted fluorescent imaging agents.
A series of novel fluorescence imaging agents that efficiently target cyclooxygenase-2 (COX-2), which is normally absent from cells, but is found at high levels in inflammatory lesions and in many premalignant and malignant tumors, are reported.
FKBP binding characteristics of cardiac microsomes from diverse vertebrates.
It can now be concluded that the association of FKBP isoforms with RyR2 is widely conserved in the hearts of different species of vertebrates.
Distance estimate of the active center of D-beta-hydroxybutyrate dehydrogenase from the membrane surface.
The spin-probe-spin-label technique has been used to estimate the distance of separation of the reactive sulfhydryl of D-beta-hydroxybutyrate dehydrogenase from the bilayer surface, and the dipolar interaction coefficient was obtained, which is related to the reciprocal of the distance to the sixth power.