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Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Interest in hot-melt extrusion techniques for pharmaceutical applications is growing rapidly with well over 100 papers published in the pharmaceutical scientific literature in the last 12 years.Expand
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Solvent selection in the preparation of poly(dl-lactide) microspheres prepared by the solvent evaporation method
Abstract Poly( dl -lactide) (PLA) microspheres containing quinidine or quinidine sulfate were prepared by the solvent evaporation technique. The successful entrapment of drug within the microspheresExpand
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  • PDF
Influence of plasticizers and drugs on the physical-mechanical properties of hydroxypropylcellulose films prepared by hot melt extrusion.
Hydroxypropylcellulose (HPC) films containing drugs or hydrophilic or hydrophobic plasticizers were prepared by a hot melt extrusion process. Polyethylene glycol 8000 (PEG 8000) 2%, triethyl citrateExpand
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Properties of hot-melt extruded tablet formulations for the colonic delivery of 5-aminosalicylic acid.
Hot-melt extruded tablets were prepared using Eudragit S 100 as the polymeric carrier to target delivery of 5-aminosalicylic acid (5-ASA) to the colon. Scanning electron microscopy, modulatedExpand
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Non-traditional plasticization of polymeric films.
  • C. Wu, J. Mcginity
  • Materials Science, Medicine
  • International journal of pharmaceutics
  • 15 January 1999
The objective of this study was to investigate the influence of methylparaben, ibuprofen, chlorpheniramine maleate and theophylline on the thermal and mechanical properties of polymeric films ofExpand
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The use of inorganic salts to improve the dissolution characteristics of tablets containing Soluplus®-based solid dispersions.
The dissolution enhancement advantages inherent to amorphous solid dispersions systems are often not fully realized once they are formulated into a solid dosage form. The objective of this study wasExpand
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Influence of Film Additives on Stabilizing Drug Release Rates from Pellets Coated with Acrylic Polymers
  • T. Maejima, J. Mcginity
  • Materials Science, Medicine
  • Pharmaceutical development and technology
  • 1 January 2001
The objective of this study was to investigate the influence of talc and triethyl citrate (TEC) on stabilizing the drug release rates following curing and storage at elevated temperature of pelletsExpand
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Pharmaceutical Applications of Hot-Melt Extrusion: Part II
The advent of high through-put screening in the drug discovery process has resulted in compounds with high lipophilicity and poor solubility. Increasing the solubility of such compounds poses a majorExpand
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Properties of melt extruded enteric matrix pellets.
The objective of this study was to investigate the properties of enteric matrix pellets that were prepared by hot-melt extrusion in a one-step, continuous process. Five polymers (Eudragit) L100-55,Expand
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Influence of methylparaben as a solid-state plasticizer on the physicochemical properties of Eudragit RS PO hot-melt extrudates.
  • C. Wu, J. Mcginity
  • Materials Science, Medicine
  • European journal of pharmaceutics and…
  • 1 July 2003
The purpose of this study was to investigate the properties of methylparaben as a solid-state plasticizer for Eudragit RS PO during a hot-melt extrusion process. Extruded matrices containingExpand
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