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Pharmaceutical Applications of Hot-Melt Extrusion: Part I
TLDR
The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.
Influence of plasticizers and drugs on the physical-mechanical properties of hydroxypropylcellulose films prepared by hot melt extrusion.
TLDR
Although the theoretical percentage of CPM on aging remained fairly constant over the processing temperature ranges in this study, the HC levels remaining in the extruded films during storage were a function of time and temperature.
Non-traditional plasticization of polymeric films.
  • C. Wu, J. Mcginity
  • Materials Science
    International journal of pharmaceutics
  • 15 January 1999
Drug Stability: Principles and Practices
TLDR
This book is a comprehensive thesis on drug stability that has been extensively discussed and illustrated with copious examples and clear definitions of the terminology that is used today.
Amorphous compositions using concentration enhancing polymers for improved bioavailability of itraconazole.
TLDR
Amorphous compositions of ITZ and enteric concentration enhancing polymers provided improved bioavailability due to enhanced intestinal targeting and increased durations of supersaturation, and the utility of CAP to maintain supersaturated concentrations, in vivo was suggested.
Pharmaceutical Applications of Hot-Melt Extrusion: Part II
TLDR
Improvements in bioavailability utilizing the hot-melt extrusion technique demonstrate the value of the technology as a potential drug delivery processing tool.
Properties of melt extruded enteric matrix pellets.
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