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ELISA and multiplex technologies for cytokine measurement in inflammation and aging research.
Over the last decade there has been an enormous expansion of research focused on defining the role of inflammation in aging, age-related diseases, disability, and frailty. The availability of methodsExpand
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Efficacy of an adjuvanted herpes zoster subunit vaccine in older adults.
BACKGROUND In previous phase 1-2 clinical trials involving older adults, a subunit vaccine containing varicella-zoster virus glycoprotein E and the AS01B adjuvant system (called HZ/su) had aExpand
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Conceptual and methodological issues relevant to cytokine and inflammatory marker measurements in clinical research
Purpose of reviewTo provide clinical investigators with an understanding of factors to consider when wishing to add cytokine and inflammatory marker measurements to their studies. RecentExpand
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Aging, frailty and age-related diseases
The concept of frailty as a medically distinct syndrome has evolved based on the clinical experience of geriatricians and is clinically well recognizable. Frailty is a nonspecific state ofExpand
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Mortality and Institutionalization Following Hip Fracture
OBJECTIVES: To identify determinants of mortality and institutionalization after hip fracture and to identify those older hip fracture patients at high risk of death or institutionalization after hipExpand
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T Cell Responses Are Better Correlates of Vaccine Protection in the Elderly1
It is commonly held that increased risk of influenza in the elderly is due to a decline in the Ab response to influenza vaccination. This study prospectively evaluated the relationship between theExpand
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Immunosenescence: what does it mean to health outcomes in older adults?
The most profound consequences of immune senescence with respect to human health are the increased susceptibility to infectious diseases and decreased vaccine efficacy. Changes in both innate andExpand
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The role of inflammation in age-related disease
The National Institutes of Health (NIH) Geroscience Interest Group (GSIG) sponsored workshop, The Role of Inflammation in Age-Related Disease, was held September 6th-7th, 2012 in Bethesda, MD. It isExpand
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Respiratory Syncytial Virus and Other Respiratory Viral Infections in Older Adults With Moderate to Severe Influenza-like Illness
Abstract Background. Few studies have prospectively assessed viral etiologies of acute respiratory infections in community-based elderly individuals. We assessed viral respiratory pathogens inExpand
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Immunosenescence: Influenza vaccination and the elderly.
Aging is associated with a decline in the normal function of the immune system, both cellular and humoral, which often leads to a state of 'immunosenescence'. It is necessary that we understand theExpand
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