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Individualization of phenytoin dosage regimens
It was concluded that the use of individual pharmacokinetic parameters is practical and is also superior to the nomogram. Expand
Population pharmacokinetic‐pharmacodynamic modeling of moxonidine using 24‐hour ambulatory blood pressure measurements
To develop a model for 24‐hour ambulatory blood pressure measurements (ABPM) that can be applied in a pharmacokinetic‐pharmacodynamic model.
Direct Renal Vasodilatation Produced by Dopamine in the Dog
It is suggested that the ability of dopamine to alter the distribution of cardiac output in favor of visceral organs may find useful clinical applications and the probable basis for the effect of intravenous dopamine infusion on renal blood flow is its direct renal vasodilating action. Expand
Comparison of the effects of dopamine, isoproterenol, norepinephrine and bradykinin on canine renal and femoral blood flow.
The ability of dopamine to dilate the renal vascular bed without producing a qualitatively similar direct effect on the femoral vascular bed sets it apart from agents such as papaverine and the nitrites. Expand
Evaluation of the pre-ejection period as an estimate of myocardial contractility in dogs.
The studies indicate that the pre-ejection period may be used as an index of myocardial contractile state in situations in which the left ventricular end-diastolic pressure is constant or proved not to vary systematically under the conditions being studied. Expand
The potential role of dopamine in the treatment of shock.
Hydralazine kinetics after single and repeated oral doses
H plasma levels were proportional to those of hydralazine in both acetylator groups and were 2.5 to 4 times as high as those of Hydralazine, which was phenotype dependent and significantly lower than those reported with nonspecific assays. Expand
Dopamine in the treatment of hypotension and shock.
Attempts to achieve myocardial stimulation without vasoconstriction have centered on the use of sympathomimetic amines with predominant beta-adrenergic activity (isoproterenol,3 or epinephrine4) or on the conjoint use of alpha-adRenergic blocking agents with amines possessing both alpha and beta activity (norepinephrine5 or metaraminol). Expand
Effects of dopamine on renal function and hemodynamics in the dog.
It was concluded that the changes in urine formation in the dog resembled those previously observed in man and were not dependent upon systemic hemodynamic changes. Expand