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Progression of lung inflammation and damage in rats after cessation of silica inhalation.
Human epidemiologic studies have found that silicosis may develop or progress even after occupational exposure has ended, suggesting that there is a threshold lung burden above which silica-inducedExpand
Freshly fractured quartz inhalation leads to enhanced lung injury and inflammation. Potential role of free radicals.
Silicosis is a devastating pulmonary disease that continues to occur in industrial workplaces. Its pathogenesis is under critical evaluation, and this report provides new concepts on the possibleExpand
In vitro studies suggest that silica-induced lung disease may be linked to processes regulated by nuclear factor- κ B (NF- κ B) activation, but this has not been examined in vivo. Rats were exposedExpand
Time course of pulmonary response of rats to inhalation of crystalline silica: histological results and biochemical indices of damage, lipidosis, and fibrosis.
Previous studies have determined that alpha-quartz (crystalline silica) can cause pulmonary inflammation, damage, and fibrosis. However, the temporal relationship between silica inhalation andExpand
Nitric oxide and reactive oxygen species production causes progressive damage in rats after cessation of silica inhalation.
Our laboratory has previously reported results from a rat silica inhalation study which determined that, even after silica exposure ended, pulmonary inflammation and damage progressed with subsequentExpand
Enhanced Pulmonary Response to the Inhalation of Freshly Fractured Silica as Compared with Aged Dust Exposure
Abstract We have reported previously that grinding crystalline silica generates radicals on its cleavage planes and that this fresh dust is more cytotoxic in vitro than aged silica. The objective ofExpand
Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silica.
In previous reports from this study, measurements of pulmonary inflammation, bronchoalveolar lavage cell cytokine production and nuclear factor-kappa B activation, cytotoxic damage, and fibrosis wereExpand
Augmentation of pulmonary reactions to quartz inhalation by trace amounts of iron-containing particles.
Fracturing quartz produces silica-based radicals on the fracture planes and generates hydroxyl radicals (.OH) in aqueous media. .OH production has been shown to be directly associated withExpand
Particle activity and in vivo pulmonary response to freshly milled and aged alpha-quartz.
This study examined the possibility of freshly fractured alpha-quartz being more toxic and inflammatory in vivo than aged quartz of the same composition and particle size. Fresh quartz was generatedExpand
Synthesis, characterization, and use of 2-[(2H9)butoxy]acetic acid and 2-(3-methylbutoxy)acetic acid as an internal standard and an instrument performance surrogate, respectively, for the gas
Abstract 2-[(2H9)Butoxy]acetic acid and 2-(3-methylbutoxy)acetic acid were synthesized, mixed with 2-butoxyacetic acid, and separated by capillary gas chromatography on a fused-silica column with aExpand