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Phospholipase A(2)s in cell injury and death.
The functions of iPLA(2), c PLA(2) and sPLA( 2) isoforms in oncosis and apoptosis, including oxidant-induced and receptor-mediated cell death is discussed, and the measurement and modulation of PLA(1) is discussed. Expand
Decreased iPLA2gamma expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis.
The results suggest that iPLA(2)gamma is required for the prevention and repair of basal lipid peroxidation and the maintenance of mitochondrial function and viability, providing further evidence for a cytoprotective role for iPLA (2)Gamma from oxidative stress. Expand
Dissociation between cellular K+ loss, reduction in repolarization time, and tissue ATP levels during myocardial hypoxia and ischemia.
Assessment of the contribution of ATP-regulated K+ channels by using simultaneous measurements of cellular K+ efflux, [K+]o, transmembrane action potentials, and tissue ATP, ADP, phosphocreatine, and creatine content in a unique isolated, blood-perfused papillary muscle preparation during hypoxia compared with ischemia found that glibenclamide partially prevented action potential shortening induced by hypoxic perfusion. Expand
Phospholipase A2 inhibitors as potential anti-inflammatory agents.
This review will focus on agents used currently to inhibit PLA(2) activity and will explore their possible therapeutic use. Expand
Identification and distribution of endoplasmic reticulum iPLA2.
Immunoblot analysis and PLA2 inhibitor studies with methyl arachidonyl fluorophosphonate and enantiomers of bromoenol lactone demonstrated that the ER-iPLA2 in rabbit kidney and heart and rat kidney is iPLA2gamma, and suggest that iPLA1gamma may play critical roles in oxidant-induced cell injury. Expand
Identification of alpha-chloro fatty aldehydes and unsaturated lysophosphatidylcholine molecular species in human atherosclerotic lesions.
It is demonstrated that plasmalogens are attacked by MPO-derived reactive chlorinating species within human atheroma, and the resultant species formed, alpha-chloro fatty aldehydes and unsaturated lysophosphatidylcholine molecular species possess proatherogenic properties. Expand
Inhibition of Platelet-Activating Factor (PAF) Acetylhydrolase by Methyl Arachidonyl Fluorophosphonate Potentiates PAF Synthesis in Thrombin-Stimulated Human Coronary Artery Endothelial Cells
It is concluded that MAFP augments thrombin-stimulated PAF production by inhibition of PAF catabolism without affecting membrane-associated iPLA2 activity. Expand
Catalytic features, regulation and function of myocardial phospholipase A2.
  • J. McHowat, M. Creer
  • Chemistry, Medicine
  • Current medicinal chemistry. Cardiovascular and…
  • 1 July 2004
Myocardial iPLA2 demonstrates unique characteristics when compared to other PLA2 isoforms described previously, including a selectivity for plasmalogen phospholipids and resistance to inhibition by methyl arachidonyl fluorophosphonate. Expand
Neural Dysfunction and Metabolic Imbalances in Diabetic Rats: Prevention by Acetyl-L-Carnitine
Observations demonstrate a link between imbalances in carnitine metabolism and several metabolic and functional abnormalities associated with diabetic polyneuropathy and indicate that decreased sciatic nerve endoneurial ATPase activity in this model of diabetes is associated with decreased DAG. Expand
Regulation of membrane-associated iPLA2 activity by a novel PKC isoform in ventricular myocytes.
Activation of membrane-associated iPLA2 is mediated by a membrane- associated novel PKC isoform in thrombin-stimulated rabbit ventricular myocytes, suggesting that a novel PKc isoform present in the membrane fraction modulates iPLA1 activity. Expand