Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Risperidone in children with autism and serious behavioral problems.
- J. McCracken, J. McGough, D. McMahon
- Psychology, MedicineNew England Journal of Medicine
- 1 August 2002
Risperidone was effective and well tolerated for the treatment of tantrums, aggression, or self-injurious behavior in children with autistic disorder and the benefit was maintained at six months.
A genomewide scan for loci involved in attention-deficit/hyperactivity disorder.
This is the first systematic genomewide linkage scan for loci influencing ADHD in 126 affected sib pairs, using a approximately 10-cM grid of microsatellite markers and indicates that there is unlikely to be a major gene involved in ADHD susceptibility in this sample.
Analysis of shared heritability in common disorders of the brain
It is demonstrated that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine, and it is shown that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures.
Diagnostic controversies in adult attention deficit hyperactivity disorder.
Competing approaches for diagnosis of adult ADHD used in clinical and research practice are described and compared and recommendations are made as a basis for clinical assessment and future research.
Efficacy and safety of immediate-release methylphenidate treatment for preschoolers with ADHD.
- L. Greenhill, S. Kollins, T. Cooper
- MedicineJournal of the American Academy of Child and…
- 1 November 2006
MPH-IR, delivered in 2.5, 5, and 7.5-mg doses t.i.d., produced significant reductions on ADHD symptom scales in preschoolers compared to placebo, although effect sizes were smaller than those cited for school-age children on the same medication.
Psychiatric comorbidity in adult attention deficit hyperactivity disorder: findings from multiplex families.
Adult ADHD is associated with significant lifetime psychiatric comorbidity that is not explained by clinical referral bias and is significantly more likely to be unskilled workers and less likely to have a college degree.
Efficacy and tolerability of lisdexamfetamine dimesylate (NRP-104) in children with attention-deficit/hyperactivity disorder: a phase III, multicenter, randomized, double-blind, forced-dose,…
Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder.
Guanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorder: a placebo-controlled trial.
- F. Sallee, J. McGough, T. Wigal, Jessica Donahue, A. Lyne, J. Biederman
- Medicine, PsychologyJournal of the American Academy of Child and…
- 1 February 2009
Guanfacine extended-release was effective in reducing symptoms of ADHD, and adverse events were mild to moderate, did not interfere with improvements in attention, and rarely led to discontinuation.