• Publications
  • Influence
Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
Abstract IL-1β-converting enzyme (ICE) cleaves pro-1L-1β to generate mature IL-1β. ICE is homologous to other proteins that have been implicated in apoptosis, including CED-3 and Nedd-2/Ich-1. WeExpand
  • 1,277
  • 32
Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock.
IL-1 beta-converting enzyme (ICE) cleaves pro-IL-1 beta to generate mature IL-1 beta. ICE is homologous to other proteins that have been implicated in apoptosis, including CED-3 and Nedd-2/lch-1. WeExpand
  • 512
  • 27
On the classic and modern theories of matching.
  • J. McDowell
  • Computer Science, Medicine
  • Journal of the experimental analysis of behavior
  • 1 July 2005
TLDR
Classic matching theory, which is based on Herrnstein's (1961) original matching equation and includes the well-known quantitative law of effect, is almost certainly false. Expand
  • 88
  • 6
  • PDF
A computational model of selection by consequences.
  • J. McDowell
  • Computer Science, Medicine
  • Journal of the experimental analysis of behavior
  • 1 May 2004
TLDR
Darwinian selection by consequences was instantiated in a computational model that consisted of a repertoire of behaviors undergoing selection, reproduction, and mutation over many generations. Expand
  • 65
  • 5
  • PDF
On the theoretical and empirical status of the matching law and matching theory.
  • J. McDowell
  • Computer Science, Medicine
  • Psychological bulletin
  • 1 September 2013
TLDR
The original and power function versions of the matching law and matching theory are mathematical accounts of continuous choice that have been applied to the behavior of many vertebrate species, including humans, and have become influential in a variety of disciplines, such as economics, behavioral pharmacology, and clinical science. Expand
  • 60
  • 4
Variable-ratio schedules as variable-interval schedules with linear feedback loops.
  • J. McDowell, J. Wixted
  • Computer Science, Medicine
  • Journal of the experimental analysis of behavior
  • 1 November 1986
TLDR
The mathematical theory of linear systems has been used successfully to describe responding on variable-interval (VI) schedules. Expand
  • 68
  • 4
  • PDF
Falsification of matching theory's account of single-alternative responding: Herrnstein's k varies with sucrose concentration.
Eight rats pressed levers for varying concentrations of sucrose in water under eight variable-interval schedules that specified a wide range of reinforcement rate. Herrnstein's (1970) hyperbolicExpand
  • 38
  • 3
  • PDF
A quantitative evolutionary theory of adaptive behavior dynamics.
  • J. McDowell
  • Computer Science, Medicine
  • Psychological review
  • 1 October 2013
TLDR
The idea that behavior is selected by its consequences in a process analogous to organic evolution has been discussed for over 100 years. Expand
  • 24
  • 3
On the falsifiability of matching theory.
  • J. McDowell
  • Psychology, Medicine
  • Journal of the experimental analysis of behavior
  • 1986
Herrnstein's matching theory requires the parameter, k, which appears in the single-alternative form of the matching equation, to remain invariant with respect to changes in reinforcement parametersExpand
  • 47
  • 2
A computational model of selection by consequences: Log survivor plots
[McDowell, J.J, 2004. A computational model of selection by consequences. J. Exp. Anal. Behav. 81, 297-317] instantiated the principle of selection by consequences in a virtual organism with anExpand
  • 20
  • 2