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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
The liver and intestine play crucial roles in maintaining bile acid homeostasis. Here, we demonstrate that fibroblast growth factor 15 (FGF15) signals from intestine to liver to repress the geneExpand
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Lipidomics reveals a remarkable diversity of lipids in human plasma1[S]
The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now aExpand
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Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance.
Animal cells control their membrane lipid composition within narrow limits, but the sensing mechanisms underlying this control are largely unknown. Recent studies disclosed a protein network thatExpand
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Regulated Accumulation of Desmosterol Integrates Macrophage Lipid Metabolism and Inflammatory Responses
Inflammation and macrophage foam cells are characteristic features of atherosclerotic lesions, but the mechanisms linking cholesterol accumulation to inflammation and LXR-dependent response pathwaysExpand
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Glioblastoma cells require glutamate dehydrogenase to survive impairments of glucose metabolism or Akt signaling.
Oncogenes influence nutrient metabolism and nutrient dependence. The oncogene c-Myc stimulates glutamine metabolism and renders cells dependent on glutamine to sustain viability ("glutamineExpand
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Liver X receptors regulate adrenal cholesterol balance.
Cholesterol is the obligate precursor to adrenal steroids but is cytotoxic at high concentrations. Here, we show the role of the liver X receptors (LXRalpha and LXRbeta) in preventing accumulation ofExpand
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25-Hydroxycholesterol suppresses interleukin-1–driven inflammation downstream of type I interferon
Bad cholesterol: Bad for bacteria, too? Why do viral infections, such as the common cold, leave people more susceptible to bacterial pneumonia? One reason is that type I interferons, secretedExpand
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A comprehensive method for extraction and quantitative analysis of sterols and secosteroids from human plasma[S]
We describe the development of a method for the extraction and analysis of 62 sterols, oxysterols, and secosteroids from human plasma using a combination of HPLC-MS and GC-MS. Deuterated standardsExpand
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Biomarkers of NAFLD progression: a lipidomics approach to an epidemic1[S]
The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely diagnosis of these different stages,Expand
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Extraction and analysis of sterols in biological matrices by high performance liquid chromatography electrospray ionization mass spectrometry.
We describe the development of a high performance liquid chromatography mass spectrometry (HPLC-MS) method that allows the identification and quantitation of sterols in mammalian cells and tissues.Expand
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