J. McCloskey

Publications308
h-index63
Citations12,974
Highly Influential Citations236
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The RNA modification database, RNAMDB: 2011 update
TLDR
The expanded future role of The RNA Modification Database will be to serve as a primary information portal for researchers across the entire spectrum of RNA-related research.
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Summary: the modified nucleosides of RNA.
TLDR
A comprehensive listing is made of posttranscriptionally modified nucleosides from RNA reported in the literature through mid-1994, with the largest number and greatest structural diversity in tRNA, 79; and 28 in rRNA, 12 in mRNA, 11 in snRNA and 3 in other small RNAs.
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The RNA Modification Database: 1999 update
TLDR
New features include capability to search database files by name or substructural features, modifications in tmRNA, and links to related data and sites.
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Mass spectrometry of mRNA cap 4 from trypanosomatids reveals two novel nucleosides.
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Posttranscriptional Modification of the Central Loop of Domain V in Escherichia coli 23 S Ribosomal RNA (*)
TLDR
Modifications have been mapped in Escherichia coli 23 S rRNA in the central loop of domain V, a region of established interaction between 23 S RNA and tRNA, and the modified adenosine was unambiguously determined to be 2-methyladenosine in the fragment 2503-m2AGp-2505.
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Posttranscriptional modification of tRNA in thermophilic archaea (Archaebacteria)
TLDR
The structural range of posttranscriptional modifications in archaeal tRNA is more extensive than previously known, demonstrating that certain tRNA modifications occur in the archaea which are otherwise unique to either the bacterial or eukaryal domain, although the overall patterns of modification are more typical of eUKaryotes than bacteria.
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An aminoacyl-tRNA synthetase that specifically activates pyrrolysine.
TLDR
In vitro data suggest that Methanosarcina cells have two pathways for acylating the suppressor tRNA(Pyl), which would ensure efficient translation of the in-frame UAG codon in case of pyrrolysine deficiency and safeguard the biosynthesis of the proteins whose genes contain this special codon.
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Dietary selenium affects methylation of the wobble nucleoside in the anticodon of selenocysteine tRNA([Ser]Sec).
TLDR
An increase in the levels of two tRNA isoacceptors involved in the insertion of selenocysteine into protein in response to certain UGA codons is demonstrated and differences in elution properties from RPC-5 columns are consistent with other experimental observations indicating that a change in tRNA conformation accompanies this methylation.
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The mechanism of adenosine to inosine conversion by the double-stranded RNA unwinding/modifying activity: a high-performance liquid chromatography-mass spectrometry analysis.
TLDR
Although the double-stranded RNA unwinding/modifying activity appears to utilize a catalytic mechanism similar to that of adenosine deaminase, coformycin, a transition-state analogue, will not inhibit the unwinding or modifying activity.
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Post-transcriptional modification in archaeal tRNAs: identities and phylogenetic relations of nucleotides from mesophilic and hyperthermophilic Methanococcales.
TLDR
Transfer RNAs from Methanococci, a lineage of methanogenic marine euryarchaea that grow over an unusually broad temperature range, were studied to determine whether modification patterns reflect the close phylogenetic relationships inferred from small ribosomal subunit RNA sequences, and to examine modification differences associated with temperature of growth.
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