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Human NCI-H295 adrenocortical carcinoma cells: a model for angiotensin-II-responsive aldosterone secretion.
Excessive secretion of aldosterone from the adrenal results in the most common form of endocrine hypertension. An understanding of the regulatory processes involved in aldosterone synthesis andExpand
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Regulation of human adrenal carcinoma cell (NCI-H295) production of C19 steroids.
The regulation of biosynthesis of the adrenal C19 steroids (the so-called adrenal androgens) remains unclear. Understanding adrenal production of C19 steroids is important when the benefits of theseExpand
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Rat P45017α from Testis: Characterization of a Full-Length cDNA Encoding a Unique Steroid Hydroxylase Capable of Catalyzing Both Δ4- and Δ5-Steroid-17,20-Lyase Reactions
A cDNA clone encoding the complete rat 17α-hydroxylase (P45017α) from testis has been identified and sequenced. The deduced amino acid sequence is found to have 69% similarity with human P45017α, 64%Expand
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Sequence and developmental expression of Cyp18, a member of a new cytochrome P450 family from Drosophila
Preliminary studies of a partial cDNA clone of the Eig17-1 gene from Drosophila melanogaster have shown that it encodes a probable cytochrome P450 of unknown function. To further characterize theExpand
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Effect of adrenocorticotropin on steroid 21-hydroxylase synthesis and activity in cultured bovine adrenocortical cells. Increased synthesis in the absence of increased activity.
The action of adrenocorticotropin (ACTH) to stimulate synthesis of steroid 21-hydroxylase was studied in bovine adrenocortical cells maintained in primary culture. Continuous treatment with ACTH (1Expand
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Effect of calcium ions on steroid-binding spectra and pregnenolone formation in rat-adrenal mitochondria.
The effect of calcium ions on steroid-induced difference spectra of cytochrome P-450, and on pregnenolone formation, has been studied in rat adrenal mitochondria. In the presence of phosphate,Expand
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3 Beta-hydroxysteroid dehydrogenase-isomerase activity in bovine adrenocortical cells in culture: lack of response to ACTH treatment.
Primary cultures of bovine adrenocortical cells (BAC) were used to determine whether the adrenal microsomal 3 beta-hydroxysteroid dehydrogenase-isomerase complex (3 beta-HSD), like the 17Expand
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Prospective evaluation of patients with suspected hip fracture and indeterminate radiographs: use of T1-weighted MR images.
To assess the diagnostic efficacy of T1-weighted magnetic resonance (MR) images when findings on radiographs of the hip are indeterminate, 20 patients with suspected hip fracture and indeterminateExpand
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