J. McCarthy

Publications91
h-index22
Citations2,051
Highly Influential Citations31
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Human NCI-H295 adrenocortical carcinoma cells: a model for angiotensin-II-responsive aldosterone secretion.
Excessive secretion of aldosterone from the adrenal results in the most common form of endocrine hypertension. An understanding of the regulatory processes involved in aldosterone synthesis and… Expand
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Regulation of human adrenal carcinoma cell (NCI-H295) production of C19 steroids.
The regulation of biosynthesis of the adrenal C19 steroids (the so-called adrenal androgens) remains unclear. Understanding adrenal production of C19 steroids is important when the benefits of these… Expand
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Experimental Endocrinology: A Sourcebook of Basic Techniques
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Rat P45017α from Testis: Characterization of a Full-Length cDNA Encoding a Unique Steroid Hydroxylase Capable of Catalyzing Both Δ4- and Δ5-Steroid-17,20-Lyase Reactions
A cDNA clone encoding the complete rat 17α-hydroxylase (P45017α) from testis has been identified and sequenced. The deduced amino acid sequence is found to have 69% similarity with human P45017α, 64%… Expand
  • 146
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Sequence and developmental expression of Cyp18, a member of a new cytochrome P450 family from Drosophila
Preliminary studies of a partial cDNA clone of the Eig17-1 gene from Drosophila melanogaster have shown that it encodes a probable cytochrome P450 of unknown function. To further characterize the… Expand
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Effect of adrenocorticotropin on steroid 21-hydroxylase synthesis and activity in cultured bovine adrenocortical cells. Increased synthesis in the absence of increased activity.
The action of adrenocorticotropin (ACTH) to stimulate synthesis of steroid 21-hydroxylase was studied in bovine adrenocortical cells maintained in primary culture. Continuous treatment with ACTH (1… Expand
  • 49
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Effect of calcium ions on steroid-binding spectra and pregnenolone formation in rat-adrenal mitochondria.
The effect of calcium ions on steroid-induced difference spectra of cytochrome P-450, and on pregnenolone formation, has been studied in rat adrenal mitochondria. In the presence of phosphate,… Expand
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CHAPTER 8 – Adrenodoxin: An Iron-Sulfur Protein of Adrenal Cortex Mitochondria
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3 Beta-hydroxysteroid dehydrogenase-isomerase activity in bovine adrenocortical cells in culture: lack of response to ACTH treatment.
Primary cultures of bovine adrenocortical cells (BAC) were used to determine whether the adrenal microsomal 3 beta-hydroxysteroid dehydrogenase-isomerase complex (3 beta-HSD), like the 17… Expand
  • 8
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Prospective evaluation of patients with suspected hip fracture and indeterminate radiographs: use of T1-weighted MR images.
To assess the diagnostic efficacy of T1-weighted magnetic resonance (MR) images when findings on radiographs of the hip are indeterminate, 20 patients with suspected hip fracture and indeterminate… Expand
  • 114
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