J. McCann

Publications49
h-index26
Citations16,400
Highly Influential Citations240
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Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.
TLDR
The methods described include the standard plate test, the use and storage of the bacterial tester strains, preparation and use of the liver homogenates, and the methods of inducing the rats for elevated microsomal enzyme activity. Expand
An empirical approach to the statistical analysis of mutagenesis data from the Salmonella test.
TLDR
A formal method of deciding which points are on the initial linear part of the curve is described, and a statistical method is proposed for analyzing these points, which provides a very satisfactory, robust method for the standard analysis of Salmonella data. Expand
Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.
TLDR
There is a high correlation between carcinogenicity and mutagenicity: 90% (156/174) of carcinogens are mutagenic in the test and despite the severe limitations inherent in defining non-carcinogenicity, few "non-Carcinogens" show any degree of mutageniability. Expand
Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction?
  • J. McCann, B. Ames
  • Medicine
  • FASEB journal : official publication of the…
  • 1 April 2008
TLDR
There is ample biological evidence to suggest an important role for vitamin D in brain development and function, however, direct effects of vitamin D inadequacy on cognition/behavior in human or rodent systems appear to be subtle, and the current experimental evidence base does not yet fully satisfy causal criteria. Expand
Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.
TLDR
The utility of a simple test on petri plates for detecting chemical carcinogens as mutagens is extended by introducing two new bacterial strains which can detect with great sensitivity many carcinogens which it did not detect before or detected with less sensitivity. Expand
An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function.
  • J. McCann, B. Ames
  • Psychology, Medicine
  • The American journal of clinical nutrition
  • 1 April 2007
TLDR
Evidence relevant to whether a causal relation exists between dietary iron deficiency with (ID+A) or without (ID-A) anemia during development and deficits in subsequent cognitive or behavioral performance is summarized. Expand
Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and…
TLDR
Evidence from several types of studies, particularly studies in animals, suggests that, within the context of specific experimental designs, changes in brain concentrations of DHA are positively associated with changes in cognitive or behavioral performance. Expand
An overview of evidence for a causal relationship between dietary availability of choline during development and cognitive function in offspring
TLDR
The evidence suggests that choline supplementation during development results in improved performance of offspring in cognitive or behavioral tests, and in changes in a variety of neurological functional indicators. Expand
Short-term tests for carcinogens and mutagens.
Adaptive dysfunction of selenoproteins from the perspective of the triage theory: why modest selenium deficiency may increase risk of diseases of aging
  • J. McCann, B. Ames
  • Medicine
  • FASEB journal : official publication of the…
  • 1 June 2011
TLDR
The same set of age‐related diseases and conditions are prospectively associated with modest Se deficiency and also with genetic dysfunction of nonessential selenoproteins, suggesting that Se deficiency could be a causal factor, a possibility strengthened by mechanistic evidence. Expand
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