Methods for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test.
- B. Ames, J. McCann, E. Yamasaki
- BiologyMutation research
- 1 December 1975
Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.
- J. McCann, E. Choi, E. Yamasaki, B. Ames
- BiologyProceedings of the National Academy of Sciences…
- 1 December 1975
There is a high correlation between carcinogenicity and mutagenicity: 90% (156/174) of carcinogens are mutagenic in the test and despite the severe limitations inherent in defining non-carcinogenicity, few "non-Carcinogens" show any degree of mutageniability.
An empirical approach to the statistical analysis of mutagenesis data from the Salmonella test.
- L. Bernstein, J. Kaldor, J. McCann, M. Pike
- Computer ScienceMutation research
- 1 August 1982
Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction?
There is ample biological evidence to suggest an important role for vitamin D in brain development and function, however, direct effects of vitamin D inadequacy on cognition/behavior in human or rodent systems appear to be subtle, and the current experimental evidence base does not yet fully satisfy causal criteria.
Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.
- J. McCann, N. Spingarn, J. Kobori, B. Ames
- BiologyProceedings of the National Academy of Sciences…
- 1 March 1975
The utility of a simple test on petri plates for detecting chemical carcinogens as mutagens is extended by introducing two new bacterial strains which can detect with great sensitivity many carcinogens which it did not detect before or detected with less sensitivity.
An overview of evidence for a causal relation between iron deficiency during development and deficits in cognitive or behavioral function.
Evidence relevant to whether a causal relation exists between dietary iron deficiency with (ID+A) or without (ID-A) anemia during development and deficits in subsequent cognitive or behavioral performance is summarized.
Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and…
Evidence from several types of studies, particularly studies in animals, suggests that, within the context of specific experimental designs, changes in brain concentrations of DHA are positively associated with changes in cognitive or behavioral performance.
Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?
A triage perspective reinforces recommendations of some experts that much of the population and warfarin/coumadin patients may not receive sufficient vitamin K for optimal function of VKD proteins that are important to maintain long-term health.
Short-term tests for carcinogens and mutagens.
- M. Hollstein, J. McCann, F. Angelosanto, W. W. Nichols
- MedicineMutation research
- 1 September 1979
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