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Updated research nosology for HIV-associated neurocognitive disorders
In 1991, the AIDS Task Force of the American Academy of Neurology published nomenclature and research case definitions to guide the diagnosis of neurologic manifestations of HIV-1 infection. Now, 16… Expand
HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy
Objectives: This is a cross-sectional, observational study to determine the frequency and associated features of HIV-associated neurocognitive disorders (HAND) in a large, diverse sample of infected… Expand
HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors
Combination antiretroviral therapy (CART) has greatly reduced medical morbidity and mortality with HIV infection, but high rates of HIV-associated neurocognitive disorders (HAND) continue to be… Expand
Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system.
OBJECTIVE To evaluate whether penetration of a combination regimen into the central nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is associated with lower… Expand
Immunocytochemical quantitation of human immunodeficiency virus in the brain: Correlations with dementia
The pathogenesis of human immunodeficiency virus (HIV)‐associated dementia is unclear, and the underlying pathological substrate has been a matter of debate. In a prospectively clinically… Expand
The International HIV Dementia Scale: a new rapid screening test for HIV dementia
Objective:HIV dementia is an important neurological complication of advanced HIV infection. The use of a cross-cultural screening test to detect HIV dementia within the international community is… Expand
Induction of monocyte chemoattractant protein-1 in HIV-1 Tat-stimulated astrocytes and elevation in AIDS dementia.
- K. Conant, A. Garzino-Demo, +5 authors E. Major
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 17 March 1998
Activated monocytes release a number of substances, including inflammatory cytokines and eicosanoids, that are highly toxic to cells of the central nervous system. Because monocytic infiltration of… Expand
HIV Dementia Scale: a rapid screening test.
- C. Power, O. Selnes, J. Grim, J. McArthur
- Journal of acquired immune deficiency syndromes…
- 1 March 1995
HIV dementia has an annual incidence of 7% after AIDS development and eventually affects 20% of all HIV-infected persons. Accurate and early diagnosis of HIV dementia can lead to optimized… Expand
HIV-associated neurologic disease incidence changes:
This study examined the temporal trends in the incidence rates of HIV dementia, cryptococcal meningitis, toxoplasmosis, progressive multifocal leukoencephalopathy, and CNS lymphoma from January 1990… Expand
HIV-associated neurocognitive disorder — pathogenesis and prospects for treatment
In the past two decades, several advancements have improved the care of HIV-infected individuals. Most importantly, the development and deployment of combination antiretroviral therapy (CART) has… Expand