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- Publications
- Influence
Neurotensin and neurotensin receptors.
- J. P. Vincent, J. Mazella, P. Kitabgi
- Chemistry, Medicine
- Trends in pharmacological sciences
- 1 July 1999
Neurotensin is a brain and gastrointestinal peptide that fulfils many central and peripheral functions through its interaction with specific receptors. Three subtypes of neurotensin receptors have… Expand
The 100-kDa Neurotensin Receptor Is gp95/Sortilin, A Non-G-Protein-coupled Receptor*
- J. Mazella, N. Zsürger, +8 authors J. P. Vincent
- Medicine, Biology
- The Journal of Biological Chemistry
- 9 October 1998
In this work, the 100-kDa neurotensin (NT) receptor previously purified from human brain by affinity chromatography (Zsürger, N., Mazella, J., and Vincent, J. P. (1994) Brain Res. 639, 245–252) was… Expand
Structure, Functional Expression, and Cerebral Localization of the Levocabastine-Sensitive Neurotensin/Neuromedin N Receptor from Mouse Brain
- J. Mazella, J. M. Botto, E. Guillemare, T. Coppola, P. Sarret, J. P. Vincent
- Biology, Medicine
- The Journal of Neuroscience
- 15 September 1996
This work describes the cloning and expression of the levocabastine-sensitive neurotensin (NT) receptor from mouse brain. The receptor protein comprises 417 amino acids and bears the characteristics… Expand
Involvement of the Neurotensin Receptor-3 in the Neurotensin-Induced Migration of Human Microglia
- S. Martin, J. Vincent, J. Mazella
- Biology, Medicine
- The Journal of Neuroscience
- 15 February 2003
Microglia motility plays a crucial role in response to lesion or exocytotoxic damage of the cerebral tissue. We used two in vitro assays, a wound-healing model and a chemotaxis assay, to show that… Expand
Localization of the Somatostatin Receptor SST2A in Rat Brain Using a Specific Anti-Peptide Antibody
- P. Dournaud, Y. Gu, A. Schonbrunn, J. Mazella, G. Tannenbaum, A. Beaudet
- Biology, Medicine
- The Journal of Neuroscience
- 15 July 1996
Biological actions of somatostatin are exerted via a family of receptors, for which five genes recently have been cloned. However, none of these receptor proteins has been visualized yet in the… Expand
Contulakin-G, an O-Glycosylated Invertebrate Neurotensin*
- A. G. Craig, T. Norberg, +13 authors B. Olivera
- Biology, Medicine
- The Journal of Biological Chemistry
- 14 May 1999
We have purified contulakin-G, a 16-amino acid O-linked glycopeptide (pGlu-Ser-Glu-Glu-Gly-Gly-Ser-Asn-Ala-Thr-Lys-Lys-Pro-Tyr-Ile-Leu-OH, pGlu is pyroglutamate) from Conus geographus venom. The… Expand
Identification of the Receptor Subtype Involved in the Analgesic Effect of Neurotensin
- I. Dubuc, P. Sarret, +8 authors J. Mazella
- Chemistry, Medicine
- The Journal of Neuroscience
- 1 January 1999
The neuropeptide neurotensin (NT) elicits hypothermic and naloxone-insensitive analgesic responses after brain injection. Recent pharmacological evidence obtained with NT agonists and antagonists… Expand
Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system
- P. Sarret, P. Krzywkowski, +5 authors A. Beaudet
- Biology, Medicine
- The Journal of comparative neurology
- 7 July 2003
The neurotensin (NT) receptor, NTS3, originally identified as the intracellular sorting protein sortilin, is a member of a recently discovered family of receptors characterized by a single… Expand
Mutagenesis and Modeling of the Neurotensin Receptor NTR1
- C. Labbé-Jullié, S. Barroso, +5 authors P. Kitabgi
- Biology, Medicine
- The Journal of Biological Chemistry
- 26 June 1998
The two neurotensin receptor subtypes known to date, NTR1 and NTR2, belong to the family of G-protein-coupled receptors with seven putative transmembrane domains (TM). SR 48692, a nonpeptide… Expand
Somatostatin-Induced Regulation of SST2A Receptor Expression and Cell Surface Availability in Central Neurons: Role of Receptor Internalization
- H. Boudin, P. Sarret, J. Mazella, A. Schonbrunn, A. Beaudet
- Biology, Medicine
- The Journal of Neuroscience
- 15 August 2000
To investigate the effects of somatostatin (somatotropin release-inhibiting factor, SRIF) on the regulation of SST2A receptors in mammalian brain, we examined how blockade of SRIF release or… Expand