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Neurotensin and neurotensin receptors.
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The 100-kDa Neurotensin Receptor Is gp95/Sortilin, A Non-G-Protein-coupled Receptor*
TLDR
Affinity labeling and binding experiments showed that the 110-kDa NT3 receptor can be partly transformed into a higher affinity by cotransfection with furin, which is the first transmembrane neuropeptide receptor that does not belong to the superfamily of G-protein-coupled receptors.
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Structure, Functional Expression, and Cerebral Localization of the Levocabastine-Sensitive Neurotensin/Neuromedin N Receptor from Mouse Brain
TLDR
This work describes the cloning and expression of the levocabastine-sensitive neurotensin (NT) receptor from mouse brain, a new NT receptor type that is 39% homologous to, but pharmacologically distinct from, the only other NTR cloned to date from the rat brain and the human HT29 cell line.
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Localization of the Somatostatin Receptor SST2A in Rat Brain Using a Specific Anti-Peptide Antibody
TLDR
The widespread distribution of the sst2A receptor in cerebral cortex and limbic structures suggests that it is involved in the transduction of both pre- and postsynaptic effects of somatostatin on cognition, learning, and memory.
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Spadin, a Sortilin-Derived Peptide, Targeting Rodent TREK-1 Channels: A New Concept in the Antidepressant Drug Design
We found that spadin, a natural peptide derived from sortilin, blocks the mouse TREK-1 channel and might be an efficient and fast-acting antidepressant.
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Involvement of the Neurotensin Receptor-3 in the Neurotensin-Induced Migration of Human Microglia
TLDR
The use of RT-PCR, photoaffinity labeling, and Western blot analysis, demonstrates that the neurotensin receptor-3 is functional and mediates the migratory actions of neurotENSin.
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Contulakin-G, an O-Glycosylated Invertebrate Neurotensin*
TLDR
It is concluded that O-linked glycosylation appears to be a highly unusual strategy for increasing the efficacy of toxins directed against neurotransmitter receptors.
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Identification of the Receptor Subtype Involved in the Analgesic Effect of Neurotensin
TLDR
It is confirmed that NTR1 is involved in the NT-elicited turning behavior and demonstrated that the NTR2 mediates NT-induced analgesia, and a close correlation between the analgesic potency of NT analogs and their affinity for the N TR2 was revealed.
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Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system
TLDR
The present study provides the first comprehensive description of the distribution of NTS3/sortilin mRNA and protein in adult rat brain using in situ hybridization and immunocytochemistry.
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Functional roles of the NTS2 and NTS3 receptors
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