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- Publications
- Influence
Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria.
- J. Kun, B. Mordmüller, +5 authors P. Kremsner
- Medicine, Biology
- The Journal of infectious diseases
- 1 August 2001
A point mutation in the promoter of the nitric oxide synthase 2 gene (NOS2), termed NOS2(Lambaréné) (NOS2-G954C), protects heterozygous carriers against severe malaria as effectively as the sickle… Expand
Incidence of invasive salmonella disease in sub-Saharan Africa: a multicentre population-based surveillance study
- F. Marks, Vera von Kalckreuth, +56 authors T. Wierzba
- Medicine
- The Lancet. Global health
- 11 February 2017
Summary Background Available incidence data for invasive salmonella disease in sub-Saharan Africa are scarce. Standardised, multicountry data are required to better understand the nature and burden… Expand
Hemoglobin variants and disease manifestations in severe falciparum malaria.
- J. May, J. Evans, +5 authors R. Horstmann
- Medicine
- JAMA
- 23 May 2007
CONTEXT
The geographical distributions of hemoglobin S (HbS), hemoglobin C (HbC), and alpha+-thalassemia (-alpha) strongly suggest balancing selection with malaria. However, whereas several studies… Expand
A randomized controlled trial of extended intermittent preventive antimalarial treatment in infants.
- R. Kobbe, C. Kreuzberg, +13 authors J. May
- Medicine
- Clinical infectious diseases : an official…
- 1 July 2007
BACKGROUND
Intermittent preventive antimalarial treatment in infants (IPTi) with sulfadoxine-pyrimethamine reduces falciparum malaria and anemia but has not been evaluated in areas with intense… Expand
Incidence and Characteristics of Bacteremia among Children in Rural Ghana
- M. Nielsen, N. Sarpong, +11 authors N. Schwarz
- Medicine
- PloS one
- 10 September 2012
The objective of the study was to describe systemic bacterial infections occurring in acutely ill and hospitalized children in a rural region in Ghana, regarding frequency, incidence, antimicrobial… Expand
Novel Human Parvovirus 4 Genotype 3 in Infants, Ghana
- Marcus Panning, R. Kobbe, +6 authors A. Eis-Hübinger
- Biology, Medicine
- Emerging infectious diseases
- 1 July 2010
Human parvovirus 4 has been considered to be transmitted only parenterally. However, after novel genotype 3 of parvovirus 4 was found in 2 patients with no parenteral risks, we tested infants in… Expand
The role of red blood cell polymorphisms in resistance and susceptibility to malaria.
- B. Lell, J. May, +10 authors P. Kremsner
- Medicine
- Clinical infectious diseases : an official…
- 1 April 1999
In regions highly endemic for Plasmodium falciparum malaria, red cell polymorphisms that confer resistance to severe disease are widespread. Sickle cell trait, alpha-thalassemia, glucose-6-phosphate… Expand
Association of the ICAM-1Kilifi mutation with protection against severe malaria in Lambaréné, Gabon.
- J. Kun, J. Klabunde, +5 authors P. Kremsner
- Biology, Medicine
- The American journal of tropical medicine and…
- 1 November 1999
The intercellular adhesion molecule-1 (ICAM-1) is thought to be a receptor that mediates binding of Plasmodium falciparum-infected erythrocytes. Especially in vital organs, the binding of parasitized… Expand
Delayed hemolysis after treatment with parenteral artesunate in African children with severe malaria--a double-center prospective study.
- T. Rolling, T. Agbenyega, +11 authors J. Cramer
- Medicine
- The Journal of infectious diseases
- 15 June 2014
BACKGROUND
Parenteral artesunate is recommended as first-line therapy for severe malaria. While its efficacy is firmly established, data on safety are still incomplete. Delayed hemolysis has been… Expand
Spatial variation of malaria incidence in young children from a geographically homogeneous area with high endemicity.
- B. Kreuels, R. Kobbe, +7 authors J. May
- Geography, Medicine
- The Journal of infectious diseases
- 2008
BACKGROUND
In sub-Saharan Africa, malaria is a leading cause of morbidity and mortality among young children. Detailed knowledge of spatial variation of malaria epidemiology and associated risk… Expand