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Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria.
A point mutation in the promoter of the nitric oxide synthase 2 gene (NOS2), termed NOS2(Lambaréné) (NOS2-G954C), protects heterozygous carriers against severe malaria as effectively as the sickleExpand
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Incidence of invasive salmonella disease in sub-Saharan Africa: a multicentre population-based surveillance study
Summary Background Available incidence data for invasive salmonella disease in sub-Saharan Africa are scarce. Standardised, multicountry data are required to better understand the nature and burdenExpand
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Hemoglobin variants and disease manifestations in severe falciparum malaria.
CONTEXT The geographical distributions of hemoglobin S (HbS), hemoglobin C (HbC), and alpha+-thalassemia (-alpha) strongly suggest balancing selection with malaria. However, whereas several studiesExpand
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A randomized controlled trial of extended intermittent preventive antimalarial treatment in infants.
BACKGROUND Intermittent preventive antimalarial treatment in infants (IPTi) with sulfadoxine-pyrimethamine reduces falciparum malaria and anemia but has not been evaluated in areas with intenseExpand
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Incidence and Characteristics of Bacteremia among Children in Rural Ghana
The objective of the study was to describe systemic bacterial infections occurring in acutely ill and hospitalized children in a rural region in Ghana, regarding frequency, incidence, antimicrobialExpand
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Novel Human Parvovirus 4 Genotype 3 in Infants, Ghana
Human parvovirus 4 has been considered to be transmitted only parenterally. However, after novel genotype 3 of parvovirus 4 was found in 2 patients with no parenteral risks, we tested infants inExpand
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The role of red blood cell polymorphisms in resistance and susceptibility to malaria.
In regions highly endemic for Plasmodium falciparum malaria, red cell polymorphisms that confer resistance to severe disease are widespread. Sickle cell trait, alpha-thalassemia, glucose-6-phosphateExpand
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Association of the ICAM-1Kilifi mutation with protection against severe malaria in Lambaréné, Gabon.
The intercellular adhesion molecule-1 (ICAM-1) is thought to be a receptor that mediates binding of Plasmodium falciparum-infected erythrocytes. Especially in vital organs, the binding of parasitizedExpand
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Delayed hemolysis after treatment with parenteral artesunate in African children with severe malaria--a double-center prospective study.
BACKGROUND Parenteral artesunate is recommended as first-line therapy for severe malaria. While its efficacy is firmly established, data on safety are still incomplete. Delayed hemolysis has beenExpand
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Spatial variation of malaria incidence in young children from a geographically homogeneous area with high endemicity.
BACKGROUND In sub-Saharan Africa, malaria is a leading cause of morbidity and mortality among young children. Detailed knowledge of spatial variation of malaria epidemiology and associated riskExpand
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