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The usefulness of simple X-ray powder diffraction analysis for counterfeit control--the Viagra example.
The X-ray diffraction method turns out to be very fast and reliable for detecting counterfeits and imitation, and it correctly predicts the presence or absence of active substance and/or particular excipients.
Formal synthesis of (-)-podophyllotoxin through the photocyclization of an axially chiral 3,4-bisbenzylidene succinate amide ester--a flow photochemistry approach.
A strategy for the stereoselective synthesis of cyclolignans related to podophyllotoxin and its derivatives and the photocyclization of a chiral atropoisomeric 1,2-bisbenzylidenesuccinate amide ester is developed.
Synthesis of Imperatorin Analogs and Their Evaluation as Acetylcholinesterase and Butyrylcholinesterase Inhibitors
The results of this study may be considered as the beginning of a search for potential anti‐Alzheimer's disease drugs based on the structure of natural furocoumarins.
On the Primary Ionization Mechanism(s) in Matrix-Assisted Laser Desorption Ionization
A mechanism is proposed for the first step of ionization occurring in matrix-assisted laser desorption ionization, leading to protonated and deprotonated matrix (Ma) molecules ([Ma + H]+ and [Ma −
Preparation and thermal stability of optically active 1,2,4-triazolium-based ionic liquids
The synthesis of optically active ionic liquids, in a four-step reaction sequence, is described. In the first step an oxirane ring of cyclohexene oxide was opened with 1,2,4-triazole, yielding a
Genistein complexes with amines: structure and properties
New amine complexes of genistein in the crystal and the solution state have been studied by X-ray crystallography and by 1H and 13C NMR spectroscopy. The gas-phase structures have been modelled with
Recognition of active ingredients in tablets by chemometric processing of X-ray diffractometric data.
The paper presents an approach to use Partial Least Squares Discriminant Analysis (PLS-DA) on XRPD dataset to build a model which recognizes a presence (or absence) of particular drug substance (acetaminophen) in unknown mixture (OTC tablet).
Hydrogen-bonded complex formation of oximes with carboxylic acids and with amides. (E)-Acetophenone oxime–benzoic acid (1/1) and (E)-benzaldehyde oxime–benzamide (1/1)
(E)-Acetophenone oxime-benzoic acid (1/1), C 7 H 6 O 2 .C 8 H 9 NO, M r =257.29, monoclinic, P2 1 /c, a=13.666 (1), b=5.413 (2), c=16.298 (1) A, β=108.55 (1) o , V=1282.7 (2) A 3 , Z=4, T=223 (2) K,
Synthesis and anti-HIV studies of 2-adamantyl-substituted thiazolidin-4-ones.
It was found that the (+)-22 isomer was predominantly responsible for the potent anti-HIV-1 activity (EC(50) value of 0.178 microM), while the levo isomers was more than 60-fold less active.
The contamination of surfaces during high-energy electron irradiation
Abstract Specimen contamination during electron-optical examination has been studied using “holey’ carbon-film specimens in a modified electron microscope. The composition of the residual gas