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'Touchdown' PCR to circumvent spurious priming during gene amplification.
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
Functional data from multiple, diverse experiments performed on a targeted 1% of the human genome as part of the pilot phase of the ENCODE Project are reported, providing convincing evidence that the genome is pervasively transcribed, such that the majority of its bases can be found in primary transcripts. Expand
Ultraconserved Elements in the Human Genome
There are 481 segments longer than 200 base pairs that are absolutely conserved between orthologous regions of the human, rat, and mouse genomes, which represent a class of genetic elements whose functions and evolutionary origins are yet to be determined, but which are more highly conserving between these species than are proteins. Expand
Long non-coding RNAs: insights into functions
The rapidly advancing field of long ncRNAs is reviewed, describing their conservation, their organization in the genome and their roles in gene regulation, and the medical implications. Expand
Extracellular DNA required for bacterial biofilm formation.
Bacterial biofilms are structured communities of cells enclosed in self-produced hydrated polymeric matrix adherent to an inert or living surface that have inherent resistance to antibiotics and host immune attack. Expand
Type IV pili and twitching motility.
- J. Mattick
- Biology, Medicine
- Annual review of microbiology
Twitching motility is a flagella-independent form of bacterial translocation over moist surfaces that is important in host colonization by a wide range of plant and animal pathogens, as well as in the formation of biofilms and fruiting bodies. Expand
The Transcriptional Landscape of the Mammalian Genome
Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development. Expand
RNAs appear to comprise a hidden layer of internal signals that control various levels of gene expression in physiology and development, including chromatin architecture/epigenetic memory, transcription, RNA splicing, editing, translation and turnover. Expand
Antisense Transcription in the Mammalian Transcriptome
Experimental evidence that perturbation of an antisense RNA can alter the expression of sense messenger RNAs is presented, suggesting that antisense transcription contributes to control of transcriptional outputs in mammals. Expand
Specific expression of long noncoding RNAs in the mouse brain
- T. Mercer, M. Dinger, S. Sunkin, M. Mehler, J. Mattick
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 15 January 2008
The results show that the majority of ncRNAs are expressed in the brain and provide strong evidence that themajority of processed transcripts with no protein-coding capacity function intrinsically as RNAs. Expand