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Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment.
Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome
- Viola Neudecker, M. Haneklaus, E. McNamee
- Biology, MedicineThe Journal of experimental medicine
- 5 June 2017
It is reported that miR-223 limits intestinal inflammation by constraining the nlrp3 inflammasome in mice, revealing a previously unappreciated role in regulating the innate immune response during intestinal inflammation.
Esophageal Microbiome in Eosinophilic Esophagitis
Diseases associated with mucosal eosinophilia are characterized by a different microbiome from that found in the normal mucosa, and microbiota may contribute to esophageal inflammation in EoE and GERD.
Interleukin 37 expression protects mice from colitis
- E. McNamee, J. Masterson, J. Rivera-Nieves
- Biology, MedicineProceedings of the National Academy of Sciences
- 22 August 2011
Mechanistically, IL-37 originating from hematopoietic cells was sufficient to exert anti-inflammatory effects because WT mice reconstituted with hIL-37tg bone marrow were protected from colitis, and IL- 37 emerges as key modulator of intestinal inflammation.
The oesophageal string test: a novel, minimally invasive method measures mucosal inflammation in eosinophilic oesophagitis
The presence of eosinophil-derived proteins in luminal secretions is reflective of mucosal inflammation in children with EoE, and the Enterotest diagnostic device is a novel, minimally invasive device for measuring oesophageal eos inophilic inflammation.
Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice
- Viola Neudecker, K. Brodsky, H. Eltzschig
- Biology, MedicineScience Translational Medicine
- 20 September 2017
Findings suggest that intercellular transfer of miR-223 from neutrophil-derived microRNAs to pulmonary epithelial cells may dampen acute lung injury through repression of PARP-1.
Tissue-Resident NK Cells Mediate Ischemic Kidney Injury and Are Not Depleted by Anti–Asialo-GM1 Antibody
Data demonstrate unanticipated specificity of anti–AsGM1 Ab depletion on NK cell subsets and reveal a new approach to study the contributions of cNK and trNK cells in vivo, and demonstrate that tr NK cells play a key role in modulating local responses to ischemic tissue injury in the kidney and potentially other organs.
Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis
A previously unrecognised role is identified in attenuating experimental colitis through limitation of neutrophil trafficking and genetic studies implicate the A2B adenosine receptor in netrin-1-mediated protection during DSS-colitis.
HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity
Overexpression of CLDN1 in HIF1β-deficient cells restores TJ structure and function and demonstrates a critical link between hypoxia-inducible factor (HIF) and claudin-1 (CLDN1).
Novel Device to Sample the Esophageal Microbiome—The Esophageal String Test
It is concluded that the minimally invasive, capsule-based string technology, the Enterotest™ can serve as a useful device for study of the esophageal microbiome.