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Recent advances in the chemistry of spinosyns.
M measurably improved field performance of synthetic spinosyn analogs relative to the natural product have now been observed.
Neural network-based QSAR and insecticide discovery: spinetoram
Launched in late 2007, spinetoram provides both improved efficacy and an expanded spectrum while maintaining the exceptional environmental and toxicological profile already established for the spinosyn chemistry.
A New Synthetic Approach to High‐Purity (15R)‐Latanoprost
This paper describes a new synthesis of latanoprost (1) that afforded high purity latanoprost in 16.9 % overall yield in eight synthetic steps from sulfone 4. The “α chain” in a derivative of the…
Synthesis of an Antibacterial Compound Containing a 1,4-Substituted 1H-1,2,3-Triazole: A Scaleable Alternative to the “Click” Reaction
- R. Hanselmann, Gabriel E. Job, G. Johnson, R. Lou, J. Martynow, Maxwell M. Reeve
- 15 January 2010
The copper-catalyzed “click” reaction of an azide with an alkyne has become a popular method to build up 1,4-substituted 1H-1,2,3-triazoles in medicinal chemistry and this approach was used on a…
Enantioselective cycloaddition via a chiral keto-ester ketene equivalent
Solid-phase synthesis of multiple classes of peptidomimetics from versatile resin-bound aldehyde intermediates.
- W. Scott, J. Martynow, J. Huffman, M. O'donnell
- Chemistry, BiologyJournal of the American Chemical Society
- 16 May 2007
A wide variety of highly substituted lactam containing peptidomimetic scaffolds are prepared by solid-phase synthesis from a single, versatile class of resin-bound aldehyde intermediates, allowing the construction of a large diversity of substitution patterns for ready use in combinatorial chemistry.
Distributed Drug Discovery, Part 2: Global Rehearsal of Alkylating Agents for the Synthesis of Resin-Bound Unnatural Amino Acids and Virtual D3 Catalog Construction
The creation of the first virtual D3 catalog is described, assembled from lists of either rehearsed or well-precedented alkylating and acylating reagents, and how the resulting catalog can be freely accessed, searched, and downloaded by the scientific community is described.
The reaction of cholesterol with ozone and alcohols: a revised mechanism and structure of the principal product
The structure of the product formed in the course of the reaction of cholesterol acetate with ozone in alcohol-containing solvents has been revised. In methanol–chloroform, it is shown to be the…
Sulphur-mediated five-membered ring expansions. Steroidal examples
The acid-catalysed ring expansion reaction of α-hydroxy dithioacetals, derivatives of 3-hydroxy-3-acetyl-14α-methyl-4-nor-5α- and 5β-cholest-8-ene, resulted in the exclusive migration of a secondary…
Preparation of Ethynylbenzene Derivatives from Substituted Benzaldehydes
- J. Martynow, R. Hanselmann, E. Duffy, Ashoke Bhattacharjee
- ChemistryOrganic Process Research & Development
- 4 April 2019
We have tested a number of synthetic methods for large-scale synthesis of targeted substituted aromatic alkyne (S)-[4-(3-chloro-5-ethynyl-4-fluoro-phenyl)-1-methyl-butyl]-carbamic acid benzyl ester…