• Publications
  • Influence
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
The mammalian target of rapamycin (MTOR) protein kinase complex is a key component of a pathway that regulates cell growth and proliferation in response to energy levels, hypoxia, nutrients andExpand
  • 622
  • 28
Transcriptional Activation of Lysosomal Exocytosis Promotes Cellular Clearance
Summary Lysosomes are cellular organelles primarily involved in degradation and recycling processes. During lysosomal exocytosis, a Ca2+-regulated process, lysosomes are docked to the cell surfaceExpand
  • 421
  • 28
The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris
Enhancing TFE3 activity to promote expression of lysosome-associated genes may be beneficial in treating lysosomal storage disorders. Regulating Lysosomes and Autophagy When deprived of nutrients,Expand
  • 294
  • 23
Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 γ–σ1 and AP-3 δ–σ3 hemicomplexes
The sorting of transmembrane proteins to endosomes and lysosomes is mediated by signals present in the cytosolic tails of the proteins. A subset of these signals conform to the [DE]XXXL[LI] consensusExpand
  • 224
  • 19
  • PDF
Rag GTPases mediate amino acid–dependent recruitment of TFEB and MITF to lysosomes
Active Rag GTPases are required for recruitment of TFEB to lysosomes and its phosphorylation by mTORC1, inhibiting its function under nutrient-rich conditions.
  • 180
  • 16
  • PDF
Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes.
Specialized cells exploit adaptor protein complexes for unique post-Golgi sorting events, providing a unique model system to specify adaptor function. Here, we show that AP-3 and AP-1 functionExpand
  • 221
  • 14
TFEB and TFE3 cooperate in the regulation of the innate immune response in activated macrophages
ABSTRACT The activation of transcription factors is critical to ensure an effective defense against pathogens. In this study we identify a critical and complementary role of the transcription factorsExpand
  • 116
  • 12
TFEB and TFE3 are novel components of the integrated stress response
To reestablish homeostasis and mitigate stress, cells must activate a series of adaptive intracellular signaling pathways. The participation of the transcription factors TFEB and TFE3 in cellularExpand
  • 112
  • 9
  • PDF
Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery.
Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. Here, we report the identification of two ubiquitouslyExpand
  • 145
  • 8
Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments
Major histocompatibility complex class II (MHC-II) molecules are composed of two polymorphic chains, α and β, which assemble with an invariant chain, Ii, in the endoplasmic reticulum. The assembledExpand
  • 111
  • 7